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Figure 1: Subgroup specific actionable molecular pathway in MB. (A) Activated canonical wingless (WNT) signaling in the WNT subgroup. Recurrently, mutated signaling intermediates are highlighted with cross symbol. (B) Integrated genomics approaches delineate recurrent alterations affecting sonic hedgehog (SHH) subgroup. (C) Recurrent SCNA suggests TGF-β signaling as a potential therapeutic target Group 3 MB. Recurrently, mutated signaling intermediates are highlighted with cross symbol. Solid and dashed arrows indicate positive and negative signaling effects, respectively

Figure 1: Subgroup specific actionable molecular pathway in MB. (A) Activated canonical wingless (WNT) signaling in the WNT subgroup. Recurrently, mutated signaling intermediates are highlighted with cross symbol. (B) Integrated genomics approaches delineate recurrent alterations affecting sonic hedgehog (SHH) subgroup. (C) Recurrent SCNA suggests TGF-β signaling as a potential therapeutic target Group 3 MB. Recurrently, mutated signaling intermediates are highlighted with cross symbol. Solid and dashed arrows indicate positive and negative signaling effects, respectively