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Figure 1: Diffuse white matter paucity and signal alteration predominantly involving bilateral frontal cortex also involving caudate nuclei, genu of internal capsule on T2-weighted with relative sparing of the temporo-occipital lobes. Spectroscopy showing decreased N-acetyl aspartic acid levels. There is macrocephaly with frontal bossing

Figure 1: Diffuse white matter paucity and signal alteration predominantly involving bilateral frontal cortex also involving caudate nuclei, genu of internal capsule on T2-weighted with relative sparing of the temporo-occipital lobes. Spectroscopy showing decreased N-acetyl aspartic acid levels. There is macrocephaly with frontal bossing