Journal of Pediatric Neurosciences
CASE REPORT
Year
: 2020  |  Volume : 15  |  Issue : 2  |  Page : 132--134

Primary hypokalemic periodic paralysis: Long-term management and complications in a child


Indar K Sharawat1, Renu Suthar2, Naveen Sankhyan2, Pratibha Singhi3 
1 Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India
2 Pediatric Neurology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
3 Pediatric Neurology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India; Pediatric Neurology and Neurodevelopment, Department of Pediatrics, Medanta, The medicity, Gurugram, Haryana, India

Correspondence Address:
Dr. Renu Suthar
Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh.
India

Hypokalemic periodic paralysis (HPP) is a rare genetically determined neuromuscular disorder caused by mutation in skeletal muscles calcium and sodium channels. It presents with recurrent episodes of flaccid paralysis. A 9-year-old girl presented with recurrent episodic flaccid quadriparesis with complete recovery in-between the episodes. Investigations during the acute episode revealed marked hypokalemia with electrocardiogram changes. Next-generation sequencing showed pathogenic missense mutation in CACNA1S gene. She responded well to oral potassium supplementation, acetazolamide, and spironolactone therapy. Muscle weakness in HPP is reversible, and long-term management reduces frequency of paralysis and prevents permanent weakness.


How to cite this article:
Sharawat IK, Suthar R, Sankhyan N, Singhi P. Primary hypokalemic periodic paralysis: Long-term management and complications in a child.J Pediatr Neurosci 2020;15:132-134


How to cite this URL:
Sharawat IK, Suthar R, Sankhyan N, Singhi P. Primary hypokalemic periodic paralysis: Long-term management and complications in a child. J Pediatr Neurosci [serial online] 2020 [cited 2020 Oct 22 ];15:132-134
Available from: https://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2020;volume=15;issue=2;spage=132;epage=134;aulast=Sharawat;type=0