Journal of Pediatric Neurosciences
ORIGINAL ARTICLE
Year
: 2016  |  Volume : 11  |  Issue : 4  |  Page : 309--315

Value of electroencephalographic monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia


Hatem Hamed Elshorbagy1, Ahmed A Azab2, Naglaa M Kamal3, Naglaa Fathy Barseem1, Mohamed M Bassiouny4, Mostafa A Elsayed2, Tohamy H Elkhouly5 
1 Department of Pediatrics, Menoufia University, Al Minufya, Egypt
2 Department of Pediatrics, Benha University, Banha, Egypt
3 Department of Pediatrics, Cairo University, Giza, Egypt
4 Department of Pediatrics, Tanta University, Tanta, Egypt
5 Department of Radiology, Benha University, Banha, Egypt

Correspondence Address:
Hatem Hamed Elshorbagy
Department of Pediatrics, Menoufi a University, Al Minufya
Egypt

Background: The values of electroencephalography (EEG) in neonatal hypoxic-ischemic encephalopathy (HIE) during therapeutic hypothermia (TH) are still uncertain. Aims: The aim of this study is to detect EEG background, the prevalence of seizures during cooling, and to determine different EEG patterns that can predict brain injury in magnetic resonance imaging (MRI). Patients and Methods: Thirty-nine newborns with HIE were subjected to TH. Continuous monitoring by video-EEG was carried out throughout cooling and during rewarming. MRI was done for all newborns after rewarming. The predictive value of EEG background for MRI brain injury was evaluated at 6-h intervals during cooling and rewarming. Results: At all-time intervals, normal EEG was associated with no or mild MRI brain injury. At the beginning of cooling, normal background was more predictive of a favorable MRI outcome than at later time points. After 24 h of monitoring, diffuse burst suppression and depressed patterns had the greatest prognostic value. In most patients, a discontinuous pattern was not associated with poor prognosis. Thirty-one percent developed electrical seizures, and 8% developed status epilepticus. Seizures were subclinical in 42%. There is a significant association between duration of seizure patterns detected on the EEG and severity of brain injury on MRI. Conclusions: Continuous EEG monitoring in newborns with HIE under cooling has a prognostic value about early MRI brain injury and identifies electrographic seizures, approximately 50% of which are subclinical. Treatment of clinical and subclinical seizure results in a reduction of the total duration of seizure pattern supports the hypothesis that subclinical seizures should be treated.


How to cite this article:
Elshorbagy HH, Azab AA, Kamal NM, Barseem NF, Bassiouny MM, Elsayed MA, Elkhouly TH. Value of electroencephalographic monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia.J Pediatr Neurosci 2016;11:309-315


How to cite this URL:
Elshorbagy HH, Azab AA, Kamal NM, Barseem NF, Bassiouny MM, Elsayed MA, Elkhouly TH. Value of electroencephalographic monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. J Pediatr Neurosci [serial online] 2016 [cited 2021 Sep 20 ];11:309-315
Available from: https://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2016;volume=11;issue=4;spage=309;epage=315;aulast=Elshorbagy;type=0