Journal of Pediatric Neurosciences
ORIGINAL ARTICLE
Year
: 2016  |  Volume : 11  |  Issue : 3  |  Page : 188--192

Pyridoxine-dependent convulsions among children with refractory seizures: A 3-year follow-up study


Sadanandavalli Retnaswami Chandra1, Thomas Gregor Issac2, Sai Deepak1, Ravi Teja2, Seby Kuruthukulangara3 
1 Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
2 Department of Clinical Neurosciences, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India
3 Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India

Correspondence Address:
Sadanandavalli Retnaswami Chandra
Professor of Neurology, Faculty Block, Neurocentre, National Institute of Mental Health and Neurosciences, Bengaluru . 560 029, Karnataka
India

Introduction: Epilepsy accounts for 1% of the global disease burden and about 8–10 million epilepsy patients live in India. About 30–40% of these patients become drug-resistant and land up with palliative or disease-modifying surgeries. This is a situation causing great concern in view of the psychosocial and economic burden on the patient and the family apart from severe cognitive and motor consequences, especially in children. Therefore, it is mandatory to have an insight into the wide spectrum of causes with reference to refractoriness to antiepileptic medications in children with epilepsy. Patients and Methods: Children admitted under our team with refractory epilepsy as per the International League Against Epilepsy (ILAE) criteria in the last 3 years were included in the study. Results: Refractory epilepsy constituted 13.3% of inpatients in the pediatric group. Males dominated with 68.9% of these patients. Nearly 34.4% of these patients were found to suffer from various neurometabolic diseases. Almost 3.5% were due to pyridoxine-dependent convulsions. This group of patients showed an excellent response to dietary manipulation, disease-modifying treatment for the metabolic disorder, and supportive small-dose anticonvulsants. During follow-up, they showed very good response with reference to global development and seizure control. Conclusion: Pyridoxine-dependent convulsions are relatively rare forming about 3.5% of refractory epilepsies in this series. With initiation of appropriate therapy, results with reference to seizure control as well as neurodevelopment became evident within 2 weeks, and at 1-year follow-up, complete independence for majority of the needed activities is achieved with minimum cost, almost zero side effects, and absolute elimination of the need for palliative surgery.


How to cite this article:
Chandra SR, Issac TG, Deepak S, Teja R, Kuruthukulangara S. Pyridoxine-dependent convulsions among children with refractory seizures: A 3-year follow-up study.J Pediatr Neurosci 2016;11:188-192


How to cite this URL:
Chandra SR, Issac TG, Deepak S, Teja R, Kuruthukulangara S. Pyridoxine-dependent convulsions among children with refractory seizures: A 3-year follow-up study. J Pediatr Neurosci [serial online] 2016 [cited 2021 May 13 ];11:188-192
Available from: https://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2016;volume=11;issue=3;spage=188;epage=192;aulast=Chandra;type=0