Journal of Pediatric Neurosciences
REVIEW ARTICLE
Year
: 2016  |  Volume : 11  |  Issue : 3  |  Page : 170--174

Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas


Mazda K Turel1, Tim-Rasmus Kiehl2, Fred Gentili1 
1 Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
2 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

Correspondence Address:
Mazda K Turel
Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street M5T 2S8 Toronto, Ontario
Canada

Delayed intracranial hemorrhage is a rare complication of treatment for central nervous system tumors. This may be secondary to malignant transformation of the tumor or vasculopathy related to radiation therapy (RT). While most reports on radiation-induced vasculopathy in children with optic pathway gliomas are associated with ischemic complications, there are only two reports of hemorrhagic complications in these patients. In both cases, the hemorrhage was asymptomatic and remote from the site of the original tumor but within the field of irradiation. We describe a female patient who underwent surgery for an optico-chiasmatic pilocytic astrocytoma (PA) at the age of 12 followed by RT at the age of 17 for tumor progression. The patient was followed with serial magnetic resonance imaging (MRI) scans showing marginal regression and no subsequent evidence of tumor recurrence, including the most recent MRI done only 6 months before the latest presentation. She then developed a symptomatic intratumoral hemorrhage at the age of 32 for which she underwent emergent surgery. To our knowledge, this is the first report of a nonaneurysmal-delayed hemorrhage within the site of previous surgery, several years after RT for a suprasellar PA. We review literature on delayed vasculopathy following the treatment of pediatric optic pathway gliomas and discuss the possible mechanisms of hemorrhage in our case. These long-term follow-up outcomes add significant insight and have implications in patient management.


How to cite this article:
Turel MK, Kiehl TR, Gentili F. Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas.J Pediatr Neurosci 2016;11:170-174


How to cite this URL:
Turel MK, Kiehl TR, Gentili F. Delayed hemorrhage after surgery and radiation in suprasellar pilocytic astrocytomas. J Pediatr Neurosci [serial online] 2016 [cited 2021 May 13 ];11:170-174
Available from: https://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2016;volume=11;issue=3;spage=170;epage=174;aulast=Turel;type=0