Journal of Pediatric Neurosciences
ORIGINAL ARTICLE
Year
: 2008  |  Volume : 3  |  Issue : 1  |  Page : 117--120

Predictive factors of seizure control in childhood onset epilepsy


Eli Shahar, Jacob Genizi 
 Child Neurology Unit and Epilepsy Service, Meyer Children Hospital, Rambam Medical Center, Rappaport School of Medicine, Haifa, Israel

Correspondence Address:
Eli Shahar
Child Neurology Unit and Epilepsy Service, Meyer Children Hospital, Rambam Medical Center, Haifa 31096
Israel

Background: Prediction of the long-term outcomes of childhood-onset epilepsy remains crucial for the future well-being of the affected children and their families and for planning proper therapeutic and educational programs. Objective: To identify and analyze the early predictive factors of seizure control in childhood-onset epilepsies referred at the age of 1 month up to the age of 18 years to the Epilepsy Service at the Meyer Children Hospital, Rambam Medical Center, Haifa, Israel. Materials and Methods: In this study, children who were newly diagnosed with epileptic disorders and treated with antiepileptic drug therapy - who became either completely controlled for at least twelve months or those remaining intractable - were included. Partially responding children were excluded from the analysis. The etiology was segregated into either symptomatic or nonsymptomatic epilepsy, referred to as idiopathic epilepsy. Results: Overall, 74 children (mean age: 4.27 4 years at the first seizure) were found eligible for analysis followed for a mean period of 4.5 years. Fifty-three (72%) children became seizure-free for a mean period of 20 months on antiepileptic drug (AED) therapy and 21 (28%) remained uncontrolled. Sixty out of 74 children (81%) had idiopathic epilepsy and 14 (19%) had symptomatic epilepsy. In those with idiopathic epilepsy, 46 (77%) children gained complete seizure control in comparison to 7 out of 14 (50%) children in the symptomatic group ( P < 0.01). Thirty-nine out of 47 (83%) children who had normal cognition became seizure-free, and 14 (52%) out of 27 mentally retarded children also became seizure-free ( P < 0.01). The outcome of seizure control was not affected by age at onset and seizure type itself during the presentation. Conclusion: The present study reveals that the single most predictive factor of a favorable seizure control is preserved cognitive function in accordance with idiopathic epilepsy. However, a fairly high number of children with impaired cognition may also achieve satisfactory seizure control.


How to cite this article:
Shahar E, Genizi J. Predictive factors of seizure control in childhood onset epilepsy.J Pediatr Neurosci 2008;3:117-120


How to cite this URL:
Shahar E, Genizi J. Predictive factors of seizure control in childhood onset epilepsy. J Pediatr Neurosci [serial online] 2008 [cited 2020 Dec 1 ];3:117-120
Available from: https://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2008;volume=3;issue=1;spage=117;epage=120;aulast=Shahar;type=0