<%server.execute "isdev.asp"%> Carbamazepine-associated drug reaction with eosinophilia and systemic symptoms syndrome Sharma A, Joshi E, Gupta N, Joshi M - J Pediatr Neurosci
home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 221      Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
  Table of Contents    
CASE REPORT
Year : 2021  |  Volume : 16  |  Issue : 1  |  Page : 55-57
 

Carbamazepine-associated drug reaction with eosinophilia and systemic symptoms syndrome


1 Department of Neurology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana (Ambala), Haryana, India
2 Department of Microbiology, Acharya Shri Chander College of Medical Sciences and Hospital, Jammu, Jammu and Kashmir, India
3 Department of Anaesthesiology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana (Ambala), Haryana, India

Date of Submission12-Sep-2015
Date of Decision20-May-2016
Date of Acceptance25-May-2020
Date of Web Publication25-Jun-2021

Correspondence Address:
Dr. Ankush Sharma
Department of Neurology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana (Ambala) 133207, Haryana.
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpn.JPN_126_15

Rights and Permissions

 

   Abstract 

Drug reaction with eosinophilia and systemic symptoms syndrome is a severe type IV (delayed T-cell-dependent reaction) hypersensitivity reaction, characterized by fever, mucocutaneous eruptions, eosinophilia, and systemic inflammatory involvement. It usually begins a few weeks after the exposure to offending drug. Commonly implicated drugs are aromatic anticonvulsants (phenytoin, phenobarbitone, and carbamazepine) and sulfa drugs (sulfonamides, sulfasalazine, and dapsone). It is a potentially life-threatening hypersensitivity reaction. Here we report a case of drug reaction with eosinophilia and systemic symptoms syndrome associated with carbamazepine, which was successfully treated with intravenous methylprednisolone.


Keywords: Epilepsy, hypersensitivity reaction, mucocutaneous eruptions


How to cite this article:
Sharma A, Joshi E, Gupta N, Joshi M. Carbamazepine-associated drug reaction with eosinophilia and systemic symptoms syndrome. J Pediatr Neurosci 2021;16:55-7

How to cite this URL:
Sharma A, Joshi E, Gupta N, Joshi M. Carbamazepine-associated drug reaction with eosinophilia and systemic symptoms syndrome. J Pediatr Neurosci [serial online] 2021 [cited 2021 Aug 1];16:55-7. Available from: https://www.pediatricneurosciences.com/text.asp?2021/16/1/55/319315





   Introduction Top


Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe type IV hypersensitivity reaction and usually begins after a few weeks of latency period. This reaction is characterized by fever, rash, lymphadenopathy, and systemic inflammatory involvement. The pathogenesis is not fully understood and may be multifactorial, involving immunological mechanisms, particularly drug detoxification pathways.[1],[2] The association of slow acetylation with an increased risk of DRESS syndrome highlights the importance of drug metabolism in its causation. It has also been suggested that concomitant human herpes virus 6 (HHV-6) infection increases the risk to develop DRESS syndrome.[3] The unpredictability, potential severity, and no consensus in management protocol makes it a major concerned entity in clinical practice.


   Case Report Top


A 13-year-old boy presented in the neurology outpatient department with symptoms suggestive of right-sided partial motor seizures with secondary generalization due to left frontal focal cortical dysplasia. He was started on carbamazepine 100mg once a day, and his dose was increased in increments of 100mg every fourth day. His seizures were controlled on 800mg of carbamazepine, and he continued with the treatment. On the 25th day of his treatment, he developed maculopapular rash all over his body, particularly severe on his face, neck, trunk, and legs [Figure 1]A and [B]. He was febrile with a temperature of 38°C. His examination revealed tender lymphadenopathy of axillary and cervical region with hepatomegaly. Rest of the systemic examination was normal. His investigations revealed hemoglobin of 12.3g/dL, total leukocyte count of 16,300 µL, differential leukocyte count—polymorphs: 54%, lymphocyte: 28%, eosinophil: 16%, monocyte: 2%, and alanine aminotransferase (ALT) and aspartate aminotransferase were more than four times the upper limit of normal. His blood and urine cultures were sterile. Chest X-ray was normal. Tests for hepatitis A, B, and C were negative. HIV serology was nonreactive. He was diagnosed as a case of DRESS syndrome, and his carbamazepine was stopped, injection methylprednisolone 1g intravenous, once a day for 5 days was started along with antihistaminics. He was shifted to levetiracetam from carbamazepine for seizure control. The patient improved over the next 2 weeks with complete resolution of maculopapular rash [Figure 1]C, and lymphadenopathy too subsided. Transaminitis resolution took another week, and he was discharged from the hospital in a hemodynamically stable state.
Figure 1: Extensive maculopapular rash involving face, neck, trunk, and legs (A, B). Complete resolution posttreatment of maculopapular rash (C)

Click here to view



   Discussion Top


DRESS syndrome was first described by Bocquet et al.[4] It is a severe type IV hypersensitivity reaction, and it usually begins a few weeks after the exposure to offending drug. Pathomechanism of DRESS syndrome is complex and is still not well understood. Plausible mechanisms could be the complex interplay of immune-mediated hypersensitivity as a result of interaction between the metabolites of drugs in a genetically susceptible individual.

In a genetically susceptible individual, drug or its metabolite gets accumulated due to altered activity of metabolizing enzymes. These metabolites then evoke drug-specific T lymphocytic reaction, leading to clinical presentation of DRESS syndrome. On the contrary, antidrug immune response or accumulated metabolites can incite “viral reactivation,” which can induce profound antiviral response leading to DRESS syndrome.[5]

Most commonly implicated drugs in DRESS syndrome are aromatic anticonvulsants (phenytoin, phenobarbitone, and carbamazepine) and sulfa drugs (sulfonamides, sulfasalazine, and dapsone).[4] Like all hypersensitivity reactions, DRESS syndrome too presents with rash, swelling, and eosinophilia, but the hallmark of the reaction is systemic inflammatory involvement of liver, heart, kidneys, and other organ systems.[4],[6] It is an underrecognized and underreported entity with no definite diagnostic criteria but with an overall mortality of approximately 10%.[4] High index of mortality makes it imperative for the treating physician to know about this disorder to manage it effectively. Most commonly used diagnostic guidelines were developed by a Japanese working group in 2007.[7] The guide lines require the following:

  1. Development of maculopapular rash after 3 weeks of initiation of offending drug


  2. Prolonged clinical symptoms 2 weeks after discontinuation of the offending drug


  3. Fever >38°C


  4. Hepatic involvement (including ALT >100 U/L)


  5. Leukocytosis >11 × 109/L or atypical lymphocytosis or eosinophil count >1.5 × 109/L


  6. Lymphadenopathy


  7. HHV-6 reactivation


Our patient met the first six criteria, and his HHV-6 DNA assay was not done.

The mainstay of treatment in such cases is prompt withdrawal of offending drug and introduction of steroids. Recently, a consensus outline for the management of such patients was given by Descamps et al.,[8] they recommended systemic corticosteroids (equivalent dose of 1mg/kg/day of prednisone) in patients with transaminase levels more than five times the upper limit of normal, pneumonia, renal impairment, cardiac involvement, or hemophagocytosis. In cases of life-threatening features, including respiratory or renal failure, they have recommended intravenous immunoglobulin in a dose of 2g/kg over 5 days. The group has also proposed the use of steroids in combination with ganciclovir in patients with signs of severity and confirmation of a major viral reactivation of HHV-6.

Our patient met the diagnostic criteria and was treated with intravenous steroids in recommended doses with an excellent outcome.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Tas S, Simonart T. Drug rash with eosinophilia and systemic symptoms (DRESS syndrome). Acta Clin Belg 1999;54: 197-200.  Back to cited text no. 1
    
2.
Roujeau JC. Treatment of severe drug eruptions. J Dermatol 1999;26:718-22.  Back to cited text no. 2
    
3.
Descamps V, Valance A, Edlinger C, Fillet AM, Grossin M, Lebrun-Vignes B, et al. Association of human herpes virus 6 infection with drug reaction with eosinophilia and systemic symptoms. Arch Dermatol 2001;137:301-4.  Back to cited text no. 3
    
4.
Bocquet H, Bagot M, Roujeau JC. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). Semin Cutan Med Surg 1996;15:250-7.  Back to cited text no. 4
    
5.
Cho Y-T, Yang C-W, Chu C-Y. Drug reaction with eosinophilia and systemic symptoms (DRESS): an interplay among drugs, viruses, and immune system. Int J Mol Sci 2017; 18:1243.  Back to cited text no. 5
    
6.
Allam JP, Paus T, Reichel C, Bieber T, Novak N. DRESS syndrome associated with carbamazepine and phenytoin. Eur J Dermatol 2004;14:339-42.  Back to cited text no. 6
    
7.
Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol 2007;156:1083-4.  Back to cited text no. 7
    
8.
Descamps V, Ben Saïd B, Sassolas B, Truchetet F, Avenel-Audran M, Girardin P, et al; Groupe Toxidermies de la Société Française de Dermatologie. [Management of drug reaction with eosinophilia and systemic symptoms (DRESS)]. Ann Dermatol Venereol 2010;137:703-8.  Back to cited text no. 8
    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
 
 
  Search
 
  
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (592 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
   Case Report
   Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed216    
    Printed2    
    Emailed0    
    PDF Downloaded22    
    Comments [Add]    

Recommend this journal