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Year : 2018  |  Volume : 13  |  Issue : 2  |  Page : 221-223

Early post-operative hemodynamic perturbation associated with topiramate-induced metabolic acidosis: A case report

1 Dept of Neuroanaesthesiology and Critical Care, AIIMS, New Delhi, India, India
2 Clinical fellow Neuroanaesthesia, Toronto Western Hospital, Toronto, Canada

Correspondence Address:
Keshav Goyal
Dept of Neuroanaesthesiology and Critical Care, AIIMS, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JPN.JPN_86_17

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Topiramate is a potent antiepileptic drug with multiple modes of action including inhibition of carbonic anhydrase activity. Inhibition of this enzyme predisposes to non-anion gap metabolic acidosis which has been amply described in the literature. However, the severity is yet to be well defined. We encountered a case of topiramate-induced non-anion gap metabolic acidosis associated with hemodynamic perturbations in an 8-year-old child in the postoperative period.


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