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 CASE REPORT
Year : 2017  |  Volume : 12  |  Issue : 1  |  Page : 32-35

Two cases of craniospinal rachischisis totalis: Role of magnetic resonance imaging in diagnosis and review of neural tube defects in the Indian context with implications for folate fortification


1 Department of Radio-Diagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
2 Department of Community Medicine, All Institute of Medical Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Nagarajan Krishnan
Department of Radio-Diagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry - 605 006
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.205632

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Craniospinal rachischisis is a rare and severe form of neural tube defects (NTDs), which is always fatal. It is characterized by anencephaly accompanied by a bony defect of the spine and exposure of neural tissue. We describe the two patients with ultrasonographic and magnetic resonance imaging appearance of craniospinal rachischisis totalis, detected antenatally at 22 and 25 weeks of gestation, and confirmed after termination of pregnancy. The multifactorial etiology of NTDs, with specific reference to folate deficiency, is discussed with possible role of folate fortification in the Indian context.






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