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Year : 2016  |  Volume : 11  |  Issue : 3  |  Page : 175-181

Heart-type fatty acid-binding protein as a predictor of cardiac ischemia in intractable seizures in children

1 Department of Pediatric, Menoufia University, Al Minufya, Egypt
2 Department of Pediatric, Benha University, Benha, Egypt
3 Department of Pediatric, Cairo University, Cairo, Egypt
4 Department of Pediatric, Tanta University, Tanta, Egypt
5 Department of Clinical Pathology, Al-Azhar University, Cairo, Egypt

Correspondence Address:
Hatem H El Shorbagy
Department of Pediatric, Menoufia University, Al Minufya
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1817-1745.193364

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Background: Children with intractable epilepsy have chronic dysfunction of the autonomic nervous system causing myocardial ischemia. Heart-type fatty acid-binding protein (H-FABP) is a sensitive biomarker for myocardial ischemia. Aims: We aimed to evaluate serum levels of H-FABP during seizures compared to their interictal levels and healthy controls and changes in heart rate (HR) and HR variability (HRV) in epileptic children with intractable seizures. Materials and Methods: We included 30 epileptic seizures in 25 children with intractable epilepsy and 30 matched controls. They were subjected to video-electroencephalography monitoring simultaneously with Holter electrocardiogram and measurement of H-FABP. Results: Mean serum levels of H-FABP were increased significantly in patients either in the ictal or interictal periods compared to that in the controls (P < 0.001 and P< 0.01, respectively). There is no significant difference in serum levels of the H-FABP in the ictal and interictal periods. The basal time domain measures of HRV were significantly lower in the patient group compared to the control group. Conclusion: H-FABP might suggest a degree of myocardial ischemia in intractable epilepsy. HRV is impaired in patients with refractory seizures.


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