<%server.execute "isdev.asp"%> Giant pediatric glioblastoma multiforme causing primary calvarial erosion and sutural diastasis presenting with enlarged head Satyarthee GD, Mahapatra A K - J Pediatr Neurosci
home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 5812      Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
  Table of Contents    
CASE REPORT
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 290-293
 

Giant pediatric glioblastoma multiforme causing primary calvarial erosion and sutural diastasis presenting with enlarged head


1 Department of Neurosurgery, Neurosciences Centre, AIIMS, New Delhi, India
2 Department of Neurosurgery, AIIMS, Bhubaneshwar, Odisha, India

Date of Web Publication18-Sep-2015

Correspondence Address:
Guru Dutta Satyarthee
Department of Neurosurgery, Room No. 714, Neurosciences Centre, AIIMS, New Delhi - 110 049
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.165728

Rights and Permissions

 

   Abstract 

Authors report a rare case of supratentorial glioblastoma multiforme in a 13-year-old boy, who had headache, vomiting and left sided hemiparesis for last 6 months. On evaluation by primary physician he was labeled as hydrocephalus in view of enlarged head with papilledema on fundoscopic evaluation and no imaging was carried out. On current admission, magnetic resonance imaging brain revealed a large heterogeneous mass lesion involving right frontoparietal region associated with massive perilesional edema causing significant mass effect. He underwent right fronto-temporal craniotomy and intraoperatively erosion of parietal bone was observed, unassociated with any extradural deposit of tumor. After surgery, he noticed improvement in headache along with hemiparesis. Primary calvarial erosion in glioblastoma is extremely rare, and there is paucity of literature as evident from the few case reports reported previously and all occurred in elderly, so current case is the first pediatric case having primary calvarial erosion. Management of such case and pertinent literature is briefly discussed.


Keywords: Calvarial destruction, enlarged skull, pediatric glioblastoma multiforme, sutural diastasis


How to cite this article:
Satyarthee GD, Mahapatra A K. Giant pediatric glioblastoma multiforme causing primary calvarial erosion and sutural diastasis presenting with enlarged head. J Pediatr Neurosci 2015;10:290-3

How to cite this URL:
Satyarthee GD, Mahapatra A K. Giant pediatric glioblastoma multiforme causing primary calvarial erosion and sutural diastasis presenting with enlarged head. J Pediatr Neurosci [serial online] 2015 [cited 2022 Oct 7];10:290-3. Available from: https://www.pediatricneurosciences.com/text.asp?2015/10/3/290/165728



   Introduction Top


Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor but considered as extremely rare in patients <30 years old. [1] The majority of the hemispheric tumors in children are gliomas, of which 6.5% of them constitute high-grade gliomas. [2],[3] The outcome of patients operated for GBM remains poor. Pediatric GBM has poor 5-year survival rates about 5-15%. [2],[3],[4],[5] We report a case of GBM in a teenage boy, where enlarged head size with sutural diastasis masquerading as hydrocephalus which delayed the primary diagnosis. After imaging, with provisional diagnosis of GBM, he underwent surgical management. Intra-operatively, erosion of skull with sutural diastases is not reported in the pediatric primary GBM; however, only reported in older ages in the form of isolated case reports. [4],[5],[6],[7],[8],[9],[10]


   Case Report Top


A 13-year-old boy resident of remote village presented with progressive headache and vomiting for last 6 months and left sided hemiparesis for 2 weeks. He first consulted local physician 4 months back, who observed large head size [Figure 1], fundus examination revealed papilledema, and a presumed diagnosis of hydrocephalus was made, subsequently frusemide and phenytoin as antiepileptic medication was started although computed tomography (CT) scan was not done. On arrival in causality at current admission, he was intubated, examination on admission revealed head was enlarged with sutural diastases, Glasgow coma scale (GCS) was E4 V2 M5, fundi showed papilledema with left facial nerve upper motor neuron paresis with hypertonia in all limbs, left sided grade 2/5 hemiparesis with exaggerated deep tendon reflexes and bilateral plantar extensor response. Hematological examination was within normal limits except hemoglobin which was 14 gm/dl, due to repeated vomiting.
Figure 1: Large size of head

Click here to view


CT scan of brain showed a large heterogeneous mass lesion over right frontoparietal region causing significant mass effect with massive perilesional edema with midline shift of 1.2 cm toward left side with effacement of ipsilateral lateral ventricle and gross subfalcine herniation with transtentotrial herniation of medial temporal lobe [Figure 2]a. The bone window showed sutural diastases [Figure 2]b. Magnetic resonance imaging brain T1-wighted image (T1-WI), axial section showed a mass lesion measuring 10.8 cm × 5.5 cm × 6.9 cm, heterogeneous with iso and hyperintense areas with area of cystic degeneration [Figure 3]a, which on T2-WI, showed heterogeneous mass with areas of hyperintensity like cerebrospinal fluid intensity with marked perilesional edema and subfalcine herniation and transtentorial herniation and gross midline shift [Figure 3]b. Contrast administration showed patchy ill-defined enhancement [Figure 3]c. A provisional diagnosis of malignant glioma was considered and planned for emergency craniotomy and resection.
Figure 2: (a) Noncontrast computed tomography head showing large heterogeneous lesion over right frontoparietal region causing significant mass effect with massive perilesional edema with midline shift of 1.2 cm toward left. (b) Bone window computed tomography head view showing sutural diastases

Click here to view
Figure 3: Magnetic resonance imaging brain (a) T1-weighted image, axial section mass lesion of size measuring 10.8 cm × 5.5 cm × 6.9 cm, heterogeneous with iso to hyperintense with area of cystic degeneration. (b) T2-weighted image, showing heterogeneous mass with areas of hyperintensity such as cerebrospinal fluid intensity with marked perilesional edema. (c) Contrast enhanced magnetic resonance imaging of the brain showing patchy mixed intensity contrast enhancing lesion

Click here to view


He underwent large, right frontotemporoparietal craniotomy. After raising scalp flap, thinned out calvaria over the frontoparietal region, was observed with sutural diastasis. The bone flap showed areas of erosion over right parietal and frontal region [Figure 4]a, and the dura was intact without evidence of deposit of tumor in the extradural space, [Figure 4]b. However, dura remained tense even after mannitol infusion and starting total intravenous anesthesia, and stopping volatile and nitrous oxide anesthetic agent, after dural opening, brain bulge was observed, tumor was reaching up-to the surface with effaced sulci and discolored cortical surface. During decompression, tumor was highly vascular with heterogeneous consistency and presence of large thrombosed vessels. Gross total excision of tumor was carried out. Intra-cavitary drain was placed. Expansible towering, lax duraplasty carried out using pericranium. In the immediate postoperative period, he was kept on ventilatory support and extubated after 2 days, postoperative CT scan head showed radical excision of lesion with good operative cavity with complete subsidence of midline shift and mass effect [Figure 5]. He improved to GCS score E4 M6 V4, tone reduced and hemiparesis improved to grade 4/5. Histopathology of specimen was WHO grade IV, GBM, on immunohistochemistry, it was glial fibrillary acidic protein positive, MIB-1 index was about 20%, positive for P53 index. The patient received postoperative radiotherapy of 54 Gy in 28 fractions and chemotherapy at the radiotherapy department. Follow-up at 6 months following surgery, he was doing well and ambulatory and regularly attending school.
Figure 4: Intra-operative photograph: (a) Bone fl ap showed areas of destruction over parietal and frontal region. (b) Grossly intact dura without evidence of extradural deposit of tumor

Click here to view
Figure 5: Noncontrast computed tomography scan (postoperative) head showed radical excision of lesion with good operative cavity with complete subsidence of midline shift and mass effect

Click here to view



   Discussion Top


GBM is most common glial tumor in adults, commonly associated with poor prognosis, with a median survival of about 12 months or less with surgery and adjuvant therapy. GBM is usually considered as rare neoplasm in patient <30 years of age, and further pediatric GBM is quite rarer accounting for approximately 6.5%. [1] However, tumors involving greater part of one hemispheric are usually gliomas, being common in both children as well as adults, and most of these are low-grade gliomas, and rarely a GBM. Further non brainstem glioblastoma in children is less common than in adults.

Pediatric GBM tends to occur in first decade of life with slight male preponderance. However, time-interval between onset of symptom and diagnosis is usually short. [2] However, current case had symptoms for last 6 months presenting with enlargement of head, sutural diastasis, which closely mimicking hydrocephalus caused delay in diagnosis, as physician advised CT scan head; however, patient could not afford imaging study especially in resource constraint country. [4] Low-grade gliomas can lead to remodeling of calvarium, due to chronic mass effect; [6],[8],[9] however, remodeling causing enlarged head size with GBM is not reported in literature in pediatric GBM. Topographically GBM is predominantly located in supratentorial region, in order of decreasing frequency most often occurs in temporal lobe (32%), frontal (31%), frontoparietal (11%), and parietal (10%), respectively. [2],[3]

Primary tumors arising from glial cell lineage predominantly affect white matter of brain. Naturally, dura provides excellent protection against extradural spread of intradural neoplasm. Calvarial erosion and transdural spread can be either primary or secondary. The primary calvarial erosion and transdural spread occur spontaneously in the absence of any prior surgical intervention or irradiation and its incidence is quite rare, [3],[4],[6] unlike the more common secondary type which occurs after previous insult or intervention including past craniotomy for tumor decompression, biopsy or repeated surgery for recurrent lesion or brachytherapy following surgical decompression. [11],[12],[13],[14],[15],[16]

However, some intracranial tumors especially meningioma are known to penetrate dura and bone and infiltrating adjoining soft tissue. However, dural invasion and calvarial destruction by GBM leading to an outward growth are extremely rare. Primary GBM does not involve normally surrounding dura and skull but reported in the form of isolated case report, which all occurred in adult or elderly population, none in the pediatric age group. [3],[4],[5],[6],[7],[8],[9],[10]

Exact mechanism of calvarial erosion and transdural spread in primary GBM is unknown. Kawano et al. postulated potential three routes for extradural spread of primary intracranial tumor first along the perivascular space along the vessel or dural sheaths, second along adjoining spinal or cranial nerves, and third by directly causing dural destruction overlying GBM. [7] Mechanism of secondary calvarial erosion and transdural spread: dural defect created during previous surgery can provide conduit for transdural migration and being further assisted by high intracranial tension secondary to recurrence of tumor, calvarial destruction and even infiltration of overlying scalp. Gelatinase activity has been implicated in GBM invading surrounding tissues and extra neural metastasis. [3],[6],[8]

Gheyi et al. reported supratentorial GBM causing skull erosions secondary to parietal GBM, reported to had calvarial involvement with associated scalp involvement in a 68-year-old male with transdural spread and microscopic invasion of dura. [3] GBM can very rarely have distant spread as reported by Kleinschmidt-Demasters, who analyzed two cases adult cases, had craniotomy surgery for tumor decompression previously for GBM, and intra-operatively both cases had evidence of dural involvement. Following surgery, both developed diffusely metastatic bone marrow involvement causing hemorrhagic diatheses from their diffuse bony disease. [15] However, the current case is unique as presentation with enlarged head size, sutural separation, and primary calvarial erosion as a combination is rare occurrence.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
   References Top

1.
Perkins SM, Rubin JB, Leonard JR, Smyth MD, El Naqa I, Michalski JM, et al. Glioblastoma in children: A single-institution experience. Int J Radiat Oncol Biol Phys 2011;80:1117-21.  Back to cited text no. 1
    
2.
Wiltshire RN, Rasheed BK, Friedman HS, Friedman AH, Bigner SH. Comparative genetic patterns of glioblastoma multiforme: Potential diagnostic tool for tumor classification. Neuro Oncol 2000;2:164-73.  Back to cited text no. 2
    
3.
Gheyi V, Hui FK, Doppenberg EM, Todd W, Broaddus WC. Glioblastoma multiforme causing calvarial destruction: An unusual manifestation revisited. AJNR Am J Neuroradiol 2004;25:1533-7.  Back to cited text no. 3
    
4.
Woodruff WW Jr, Djang WT, Voorhees D, Heinz ER. Calvarial destruction: An unusual manifestation of glioblastoma multiforme. AJNR Am J Neuroradiol 1988;9:388-9.  Back to cited text no. 4
    
5.
Shuangshoti S, Kasantikul V, Suwanwela N. Spontaneous penetration of dura mater and bone by glioblastoma multiforme. J Surg Oncol 1987;36:36-44.  Back to cited text no. 5
    
6.
Rainov NG, Holzhausen HJ, Meyer H, Burkert W. Local invasivity of glioblastoma multiforme with destruction of skull bone. Case report and review of the literature. Neurosurg Rev 1996;19:183-8.  Back to cited text no. 6
    
7.
Kawano N, Yada K, Ogawa Y, Sasaki K. Spontaneous transdural extension of malignant astrocytoma. Case report. J Neurosurg 1977;47:766-70.  Back to cited text no. 7
    
8.
Sanerkin NG. Transdural spread of glioblastoma multiforme. J Pathol Bacteriol 1962;84:228-33.  Back to cited text no. 8
    
9.
Osborn RE, Ley CE. Astrocytoma with calvarial erosion. AJNR Am J Neuroradiol 1986;7:178.  Back to cited text no. 9
    
10.
Harwood-Nash DC, Fitz CR. Brain neoplasms. In: Neuroradiology in Infants and Children. St. Louis: Mosby-Year Book; 1976. p. 667-8.  Back to cited text no. 10
    
11.
Murphy MN, Korkis JA, Robson FC, Sima AA. Gliosarcoma with cranial penetration and extension to the maxillary sinus. J Otolaryngol 1985;14:313-6.  Back to cited text no. 11
    
12.
Houston SC, Crocker IR, Brat DJ, Olson JJ. Extraneural metastatic glioblastoma after interstitial brachytherapy. Int J Radiat Oncol Biol Phys 2000;48:831-6.  Back to cited text no. 12
    
13.
Horiuchi T, Osawa M, Itoh N, Kobayashi S, Nitta J, Hongo K. Extradural extension of glioblastoma multiforme into the oral cavity: Case report. Surg Neurol 1996;46:42-6.  Back to cited text no. 13
    
14.
Pompili A, Calvosa F, Caroli F, Mastrostefano R, Occhipinti E, Raus L, et al. The transdural extension of gliomas. J Neurooncol 1993;15:67-74.  Back to cited text no. 14
    
15.
Kleinschmidt-Demasters BK. Diffuse bone marrow metastases from glioblastoma multiforme: The role of dural invasion. Hum Pathol 1996;27:197-201.  Back to cited text no. 15
    
16.
Verma SK, Kumar A, Singh PK, Bindra A, Sagar S, Sharma BS. Glioblastoma multiforme presenting as a fungating mass extending through previous craniotomy site. Neurol India 2013;61:325-6.  Back to cited text no. 16
[PUBMED]  Medknow Journal  


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]


This article has been cited by
1 Supratentorial extraventricular ependymoma presenting calvarial erosion: A report of 3 cases
Yuki Takaki, Satoshi Tsutsumi, Shinichiro Teramoto, Senshu Nonaka, Hidehiro Okura, Takamoto Suzuki, Hisato Ishii
Radiology Case Reports. 2021; 16(10): 3003
[Pubmed] | [DOI]
2 Cranial solitary osseous plasmacytoma and subjacent amyloid deposition in a dog
Emili Alcoverro, Daniel Sánchez-Masián, Emanuele Ricci, Frederike Schiborra, Joanna Morris, Riccardo Finotello
Clinical Case Reports. 2020; 8(12): 2498
[Pubmed] | [DOI]
3 Atypical meningeal hemangiopericytoma presenting with punched-out calvarial erosion
Kazuki Nishioka, Satoshi Tsutsumi, Shinichiro Teramoto, Senshu Nonaka, Hidehiro Okura, Takamoto Suzuki, Hiroshi Izumi, Hisato Ishii
Radiology Case Reports. 2020; 15(11): 2129
[Pubmed] | [DOI]



 

Top
Print this article  Email this article
 
 
  Search
 
  
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (841 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
   Case Report
   Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed2547    
    Printed57    
    Emailed0    
    PDF Downloaded66    
    Comments [Add]    
    Cited by others 3    

Recommend this journal