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Year : 2014  |  Volume : 9  |  Issue : 2  |  Page : 97-99

Neonatal seizures: Predictors of adverse outcome

Department of Pediatrics, Sree Gokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India

Correspondence Address:
Veena Anand
Prasanth, Vellamanal, Mayyanad, P.O., Kollam - 691 303, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1817-1745.139261

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Context: Early detection of predictors of adverse outcome will be helpful for neonatologists to plan management, follow up and rehabilitation in advance so that neurological disability can be minimised. Aims: The purpose of this study was to determine the factors affecting the adverse outcome of neonatal seizures. Settings and Design: This is a prospective study conducted in the neonatal unit of a tertiary care hospital. One hundred and eight newborns consecutively admitted with seizures were included in this study. Materials and Methods: Data was collected regarding perinatal history and seizure and evaluated for etiology. We conducted a retrospective analysis to identify the factors associated with adverse outcome after neonatal seizures. Statistical Analysis Used: Chi-square test with degree of freedom = 1 was used to find the variables significantly associated with adverse outcome (P < 0.05). Results: Gestational age, birth weight, Apgar score at 5 min, seizure onset <24 hrs, status epilepticus, radiological findings and EEG findings were significantly associated with outcome. Conclusion: Mortality and severe neurological impairment after neonatal seizure is associated with prematurity, LBW, low Apgar score at 5 min, etiologies like meningitis, sepsis, severe HIE, brain malformations, grade 3 or 4 IVH or intracranial haemorrhage, seizure onset <24 hours, presence of status epilepticus, severely abnormal radiological and EEG findings.


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