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Year : 2012  |  Volume : 7  |  Issue : 1  |  Page : 19-22

The efficacy and side effects of levetiracetam on refractory epilepsy in children

Department of Pediatric Neurology, Cukurova University Medical Faculty, Adana, Turkey

Correspondence Address:
Faruk Incecik
Toros mah, 40 Sok, Omer Bayram Havuz Apt, Adana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1817-1745.97614

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Objective: To evaluate the efficacy and tolerability of levetiracetam (LEV) add-on therapy in children with refractory epilepsy. Materials and Methods: We evaluated 102 children (56 boys, 46 girls, mean age 96.00 ± 31.15 months) with refractory epilepsy. Patients received LEV as add-on therapy. Changes in seizure frequency and adverse events were observed. Follow-up was conducted at least 6 months after treatment. Results: In total, 46 (45.1%) of the 102 children achieved more than 50% seizure frequency reduction, and 16 (15.6%) of these were seizure free. LEV reduced seizure frequency by at least 50% in 58.3% of patients with partial seizures, in 32.0% of patients with primary generalized seizures, and in 17.6% of patients with both partial and generalized seizures. Conclusion: Our results confirm that LEV, as add-on therapy, was effective in reducing seizure frequency in a variety of seizure types but seems most effective for partial-onset seizures. LEV was also well-tolerated in children.


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