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ORIGINAL ARTICLE |
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| Year : 2011 | Volume
: 6
| Issue : 2 | Page : 106-109 |
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Prevalence of migraine and tension-type headache among school children in Yazd, Iran
H Fallahzadeh, M Alihaydari
Department of Biostatistics and Epidemiology, Daneshjoo Boulevard, Health School, Shahid Sadoughi University of Medical Sciences-Yazd, Iran
| Date of Web Publication | 13-Feb-2012 |
Correspondence Address:
H Fallahzadeh
Department of Biostatistics and Epidemiology, Daneshjoo Boulevard, Health School, Shahid Sadoughi University of Medical Sciences-Yazd
Iran
 Source of Support: Grant 388 from Yazd University of Medical Sciences, Conflict of Interest: None  | Check |
DOI: 10.4103/1817-1745.92818
 Abstract | | |
Objective: The etiology and pathogenesis of migraine and other types of headache are still under discussion. The aim of this study was to investigate the prevalence of migraine and tension-type headache and its association with demographic variables among schoolchildren. Materials and Methods: A cross-sectional study was performed on 930 school children (aged 12-14 years) through cluster sampling method. International Headache Society criteria were used for diagnosis. Descriptive statistics and logistic regression were used for data analysis. Results: The prevalence of migraine headache was 12.3% (95% CI: 10.2-14.4) and tension-type headache was 4.2% (95% CI: 2.9-5.6). The factor associated with migraine in multivariate analysis were age and sleep disturbances. Conclusions: Migraine is common among school children, although it may be under-recognized. Because children with migraine and tension-type headache have a high prevalence of sleep disturbances, they should always be evaluated for the presence of sleep problems.
Keywords: Epidemiology, headache, migraine, prevalence, tension-type headache
How to cite this article:
Fallahzadeh H, Alihaydari M. Prevalence of migraine and tension-type headache among school children in Yazd, Iran. J Pediatr Neurosci 2011;6:106-9 |
| Introduction | |  |
Migraine is a chronic neurologic disorder characterized by recurrent episodes of headache and associated symptoms (eg, nausea, sensitivity to light and noise) that typically last from 4 to 72 h. [1] In Western countries, the condition affects approximately 11% of the adult population. [2] Primary headaches occur frequently in childhood. In large population-based studies, approximately 10% of children meet International Headache Society (IHS) criteria for migraine headache. [3],[4]
The prevalence rate of migraine was reported to be 78% (weekly), among 10-to 17-year-old Dutch; 10.6% among Aberdeen (United Kingdom) 5- to 15-year-old schoolchildren, 3.4% among Istanbul (Turkey) schoolchildren,11.3% (lifetime) among Cotonou (Benin) University students, 6.1% among Shiraz (Iran) school children, and 26.5%(lifetime) in Norway population. [3],[5],[6],[7],[8],[9] Tension-type and nonspecific recurrent headaches have been reported in another 2%-6% of children. [3],[8]
Organic factors are essential in migraine and include heredity, neurogenic inflammation, neuropeptides, and neurophysiological changes. [10],[11],[12] Psychosocial mechanisms include social and economic status, residence and housing conditions, family conditions, psychiatric and somatic comorbidity, and behavioral problems. [13] Headache is more common among children with lower socioeconomic groups. [6] A higher number of persons per room and a lower housing standard were associated with a higher frequency of headache. [14] Another study determined children with migraine headaches have a high prevalence of sleep disturbances. [15],[16]
This study was conducted to determine the prevalences of migraine and tension-type headache among schoolchildren of Yazd (Iran) and to identify associated risk factors.
| Materials and Methods | | |
Place of study
Yazd, one of the large cities of the Islamic Republic of Iran, is the center of Yazd Province. The city is located 750 km south of the capital Tehran. It has a dry climate and a population of 750,000 people.
Type of study
This was a cross-sectional study among school-aged children during the academic year 2008-2009.
Sampling method and sample size
The sample size was calculated as 930 individuals based on a prevalence of 10% with a margin of error of 2%, a confidence interval (CI) of 95%, and a design effect of 1.5. The city Yazd has 32 schools. All schools were listed and among them, 11 were selected by the systematic sampling method. Three classes were also randomly chosen from every school and in total 33 classes were selected from all the schools. The data were collected in 2008.
The questionnaire
The questions about the demographic data included the name, age, sex, school name, and class name of the student. A face-to-face interview was conducted by qualified physician trained for this study for all schoolchildren. The details of headache history and sleep patterns (sleep disturbances including insufficient sleeping, oversleeping) were recorded. A semi-structured questionnaire [8] was used to screen headache among the children, applying the IHS classification for migraine and tension-type headache [Table 1]. [1] Questions about headache wer e about experience of headache over the past year, severity, duration, times, associated symptoms (nausea, vomiting, photophobia, and phonophobia), and family history. | Table 1: Diagnostic criteria for tension-type headache and migraine (adapted from the international headache society[1]
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Statistical methods
Statistical analyses were performed using SPSS for Windows Release 15.0. Usual descriptive analysis was used: Means and standard deviations, frequencies and confidence intervals (CI). To estimate the association between migraine and covariates, odds ratios and their CI at 95% were estimated for the categories of age, sex, family history of migraine. Pearson's Chi-square test was used for the comparison of categorical variables. A logistic regression model has been established.We included in the initial model all the variables significantly associated in univariate analysis. The level of significance has been fixed to 0.05 throughout analysis.
| Results | | |
In total, 930 students aged 12-15 years participated in this study with a mean and a standard deviation of 13.3 ± 0.98 years; a total of 469 males (50.5%) and 460 females (49.5%). Sociodemographic variables and headache characteristics of the participants are presented in [Table 2]. | Table 2: Demographic variables and headache characteristics of the participants
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The prevalence of migraine was 12.3% (95% CI: 10.2-14.4) (n=114), and the prevalence of tension headache was 4.2% (95% CI: 2.9-5.6) (n=39) [Table 2].
[Table 3] shows the prevalence of migraine according to the age, sex, familial history of migraine,and the duration of headache history and severity of pain. The rates of migraine and tension headache among students with a family history of headache groups were 13.8% and 5.1%, respectively (P<0.01). | Table 3: The association of several characteristics with migraine and tension-type headache presence: Univariate analysis
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The rate of absence from school among migraine and tension headache groups was 48.2% and 20.5%, respectively. In children with migraine and tension headache the prevalence of insomnia were 70.1% and 64.1%. The prevalence of visual and somatic aura in migraine groups were 42.9% and 49.1%, moreover in tension headache group that were 33.4% and 38.5%; 26.5% of patients with migraine had visited a physician but only 4% of patients with tension headache reported this history.
Univariate analysis showed that age, gender, family history of headache among first-degree relatives, insomnia, and visual aura and somatic aura were significantly associated with the presence of migraine (P<0.05), moreover we found that only family history of headache among first-degree relatives were significantly associated with the presence of tension-type headache (P<0.05) [Table 3].
Logistic regression analysis was conducted separately for migraine and tension headache groups [Table 4]. The results of logistic regression showed that insomnia and age were associated with migraine headache after adjusting for age, sex, and family history of headache (odds ratio [OR]=1.85, 95% CI: 1.19-2.89, P=0.006). There was no factor associated with tension headache in multivariate analysis. | Table 4: The association of several characteristics with migraine and tension-type headache presence:
Multivariate analysis
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| Discussion | | |
This study examined the prevalence of migraine and tension-type headache with IHS criteria. [1] The sampling was performed using the technique of cluster sampling, which limited the selection bias and we obtained good precision because we had a large sample size.
In this study, the prevalence of migraine was 12.3%. It was close to 10.6% among Aberdeen (United Kingdom)school children, but twice the prevalence reported by Ayatollahi [8] among Iranian school children. [3] In an Italian study, the overall migraine prevalence was 3%. [17]
The prevalence of tension-type headache was determined as 4.2%, which is lower than that observed in other studies. [18] A previous study performed among school children in southern Iran in 1998 also showed a higher prevalence (12.1%) of tension-type headache. [8] In a Saudi Arabian study, the tension-type headache prevalence was 14%. [3] The low prevalence of tension-type headache in our study compared with other studies may reflect age-related psychological differences.
The prevalence of migraine in our study was slightly higher in males compared with females.
According to Isik et al., [6] the prevalence of migraine in males was higher than that in females, which is consistent with our study results. Although we found an association of migraine with age, we did not observe an increase in the prevalence of migraine with advancing age, as previously described. According to Stewart et al., [19] the incidence of migraine without aura in female peaked between the age of 14 and 17 years. Isik et al. [16] and Scher et al. [2] showed that the prevalence of migraine increases with age.
The rate of family history of headache was 80% in our study, which is consistent with previous studies. [16],[21] In this study, migraine headache was also associated with insomnia and the OR of migraine headache in school children with insomnia was 1.8. In previous studies, increased sleepiness was associated with headache in children. [16],[22] Our results are concordant with these investigations. Miller et al. [22] showed that children with migraine have a high prevalence of sleep disturbances. Isik et al. [16] showed that migraine was associated with parasomnias. Bedtime struggle, teeth grinding, sleep vocalizations, nightmares, and sleep walking rates were highest among the migraine group, followed by the no migraine and no headache groups. The direction of the relationship between headaches and sleep is unknown. Regardless, interventions targeting sleep habits may improve headache symptoms. In conclusion, the results of the study show that migraine is common among school children and sleep disturbances might be a risk factor for migraine headache.
| Acknowledgment | | |
This study was supported by grant 388 from Yazd University of Medical Sciences.
| References | | |
| 1. | Headache classification committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalagia 1988;8Supp l7:1-96. 
|
| 2. | Scher AI, Stewart WF, Lipton RB. Migraine and headache: A meta-analytic approach. In: Crombie IK, editor. Epidemiology of Pain. Seattle, WA: IASP Press; 1999. p. 159-70.
|
| 3. | Abu-Arefeh I, Russell G. Prevalence of headache and migraine in schoolchildren. BMJ 1994;309:765-9.
|
| 4. | Lee L, Olness K. Clinical and demographic characteristics of migraine in urban children. Headache 1997;37:269-76.
|
| 5. | Bandell-Hoekstra IE, Abu-Saad HH, Passchier J, Frederiks CM, Feron FJ, Knipschild P. Prevalence and characteristics of headache in Dutch schoolchildren. Eur J Pain 2001;5:145-53.
|
| 6. | Iºik U, Topuzoðlu A, Ay P, Ersu RH, Arman AR, Onsüz MF, et al. The prevalence of headache and its association with socioeconomic status among schoolchildren in Istanbul, Turkey. Headache 2009;49:697-703.
|
| 7. | Adoukonou T, Houinato D, Kankouan J, Makoutode M, Paraiso M, Tehindrazanarivelo A, et al. Migraine among university students in Cotonou (Benin). Headache 2009;49:887-93; discussion 894.
|
| 8. | Ayatollahi SM, Moradi F,Ayatollahi SA. Prevalence of migraine and tension type headache in for adolescent girls of Shiraz (Southern Iran). Headache 2002;42:287-90.
|
| 9. | Russell MB, Kristiansen HA, Saltyte-Benth J, Kvaerner KJ. A cross-sectional population-based survey of migraine and headache in 21,177 Norwegians: The Akershus sleep apnea project. J Headache Pain 2008;9:339-47.
|
| 10. | Russell MB, Iselius L, Olesen J. Migraine without and migraine with aura are inherited disorders. Cephalalgia 1996;16:305-9.
|
| 11. | Edvinsson L, Goadsby PJ. Neuropeptides in the cerebral circulation: Relevance to headache. Cephalalgia 1995;15:272-6.
|
| 12. | Zang Z, Winborn CS, Marquez de Prado B, Russo AF. Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1in the trigeminal ganglion. J Neurosci 2007;27:2693-703.
|
| 13. | Rasmussen BK. Migraine and tension-type headache in a general population: Psychosocial factors. Int J Epidemiol 1992;21:1138-43.
|
| 14. | Sillanpaa M, Piekkala P, Kero P. Prevalence of headache at preschool age in an unselected child population. Cephalalgia 1991;11:239-42.
|
| 15. | Carlsson J. Prevalence of headache in schoolchildren: Relations to family and school factors. Acta Paediatr 1996;85:692-6.
|
| 16. | Isik U, Ersu RH, Ay P, Save D, Arman AR, Karakoc F, et al. Prevalence of headache and its association with sleep disorders in children. Pediatr Neurol 2007;36:146-51.
|
| 17. | Raieli V, Raimondo D, Cammalleri R, Camarda R. Migraine headache in adolescents: A student population-based study in Monreale. Cephalalgia 1995;15:5-12.
|
| 18. | Wöber-Bingöl C, Wöber C, Wagner-Ennsgraber C, Zebenholzer K, Vesely C, Geldner J, et al. IHS criteria and gender: A study on migraine and tension-type headache in children and adolescents. Cephalalgia 1996;16:107-12.
|
| 19. | Stewart WF, Linet MS, Celentano DD, Van Natta M, Ziegler D. Age and sex specific incidence rates of migraine with and without visual aura. Am J Epidemiol 1991;134:1111-20.
|
| 20. | Hernandez-Latorre MA, Macaya Ruiz A, Roig M. Clinical characteristics of migraine in childhood. Rev Neurol 2001;33:708-15.
|
| 21. | Bruni O, Fabrizi P, Ottaviano S, Cortesi F, Giannotti F, Guidetti V. Prevalence of sleep disorders in childhood and adolescence with headache: A case-control study. Cephalalgia 1997;17:492-8.
|
| 22. | Miller VA, Palermo TM, Powers SW, Scher MS, Hershey AD. Migraine headaches and sleep disturbances in children. Headache 2003;43:362-8.
|
[Table 1], [Table 2], [Table 3], [Table 4]
| This article has been cited by | | 1 |
Epidemiology of migraine and headache in children and adolescents topical collection on childhood and adolescent headache |
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| Wöber-Bingöl, C. | | Current Pain and Headache Reports. 2013; 17(6) | | [Pubmed] | | | 2 |
Migraine types and triggering factors in children |
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| Biglari, H.N. and Karimzadeh, P. and Kord-Kheyli, M.M. and Hashemi, S.M. | | Iranian Journal of Child Neurology. 2012; 6(2): 33-38 | | [Pubmed] | |
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