Journal of Pediatric Neurosciences
REVIEW ARTICLE
Year
: 2019  |  Volume : 14  |  Issue : 4  |  Page : 180--185

Anti-N-methyl-d-aspartate receptor encephalitis: A case series and review of the literature


Cheri M John1, Deepa E Mathew2, Maysara Abdelaziz3, Adel A H Mahmoud4, Ali D AlOtaibi6, Aman P S Sohal5 
1 Angels Speciality Clinic, Chennai, Tamil Nadu, India
2 Apollo Speciality Hospital, Chennai, Tamil Nadu, India
3 St Helens and Knowsley NHS Trust, Prescot, United Kingdom
4 National Neuroscience Institute, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia
5 Neuropedia Children's Neuroscience Center, Dubai, United Arab Emirates

Correspondence Address:
Dr. Cheri M John
Angels Speciality Clinic, AL-190, 1st Street, 12th Main Road, Anna Nagar, Chennai 600040, Tamil Nadu.
India

Anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis is a potentially severe form of encephalitis associated with antibodies against NR1 and NR2 subunits of the NMDAR. Anti-NMDAR encephalitis is a treatable cause of encephalitis. An underlying tumor should be actively looked for as this is also considered to be a paraneoplastic syndrome. We report two children with anti-NMDAR encephalitis with a literature review of current evidence in diagnosing and managing this rare condition. Resection of the tumor, glucocorticoids, intravenous immunoglobulin, and plasma exchange often result in improvement, usually within four weeks. Outcome corresponds with the rapidity of commencing appropriate treatment.


How to cite this article:
John CM, Mathew DE, Abdelaziz M, Mahmoud AA, AlOtaibi AD, Sohal AP. Anti-N-methyl-d-aspartate receptor encephalitis: A case series and review of the literature.J Pediatr Neurosci 2019;14:180-185


How to cite this URL:
John CM, Mathew DE, Abdelaziz M, Mahmoud AA, AlOtaibi AD, Sohal AP. Anti-N-methyl-d-aspartate receptor encephalitis: A case series and review of the literature. J Pediatr Neurosci [serial online] 2019 [cited 2020 Jan 28 ];14:180-185
Available from: http://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2019;volume=14;issue=4;spage=180;epage=185;aulast=John;type=0