Journal of Pediatric Neurosciences
CASE REPORT
Year
: 2019  |  Volume : 14  |  Issue : 3  |  Page : 140--142

Transfusion-related acute lung injury due to iatrogenic IVIG overdose in Guillain–Barre syndrome


Sanghamitra Ray, Rakesh Kumar Gupta, Deepti Jain 
 Department of Paediatrics, Dr. Baba Saheb Ambedkar Medical College and Hospital, Rohini, New Delhi, India

Correspondence Address:
Dr. Sanghamitra Ray
Flat No. 176, DDA SFS Flat, Pocket-1, Sector-1, Dwarka 110075, New Delhi.
India

Transfusion-related acute lung injury (TRALI) is a transfusion-related adverse effect associated with high mortality, manifesting with acute respiratory distress and with features of non-cardiogenic pulmonary edema. It is rarely reported following intravenous immunoglobulin (IVIG) infusion and is even rarer in pediatric population. We here present a 12-year-old female child who presented as a case of acute flaccid paralysis and was diagnosed clinically as Guillain–Barre syndrome. As per protocol, she was given IVIG for 4 of the 5 days therapy at the dose of 0.4mg/kg/day before the patient went to another hospital. Subsequently in the next 1 week, she received two more courses of IVIG in two different hospitals following which she developed respiratory distress and was again admitted in our hospital. A diagnosis of TRALI was leveled on clinical ground because of IVIG overdose. Patient subsequently improved on high-flow oxygen therapy and conservative management. This unfortunate case of iatrogenic IVIG overdose just reinforces the fact of proper documentation of treatment to avoid such mishap and also prompt diagnosis and management of this least recognized entity of TRALI.


How to cite this article:
Ray S, Gupta RK, Jain D. Transfusion-related acute lung injury due to iatrogenic IVIG overdose in Guillain–Barre syndrome.J Pediatr Neurosci 2019;14:140-142


How to cite this URL:
Ray S, Gupta RK, Jain D. Transfusion-related acute lung injury due to iatrogenic IVIG overdose in Guillain–Barre syndrome. J Pediatr Neurosci [serial online] 2019 [cited 2019 Nov 15 ];14:140-142
Available from: http://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2019;volume=14;issue=3;spage=140;epage=142;aulast=Ray;type=0