Journal of Pediatric Neurosciences
ORIGINAL ARTICLE
Year
: 2006  |  Volume : 1  |  Issue : 2  |  Page : 49--55

Medulloblastoma in children: Birmingham experience


Anil Sivasankaran, Spyros Sgouros, Richard Walsh, Anthony Hockley 
 Birmingham Children's Hospital, Birmingham, United Kingdom

Correspondence Address:
Anil Sivasankaran
67, Persiaran Blm 2, Bandar Laguna Merbok, 08000, Sungai Petan, Kedah, Malaysia

A retrospective review of 41 children diagnosed with medulloblastoma in Birmingham (United Kingdom) between 1992-2002 presented. The age of the patients ranged from 2 weeks to 14.1 years (mean 5.89 years) and the mean follow-up was 3.8 years. Children less than 3 years of age fared worse than those over 3 years. The 5-year survival with total and subtotal tumor excision was 61.3 and 40% respectively. Those children who received radiotherapy following surgery had an improved survival of 68% at 5 years as compared to 18% in those who did not receive irradiation. With regards to chemotherapy, the 5-year survival rates were 57% in those who received it and 52% in those who did not. The overall survival was 62% at 5 years for those patients who had postoperative combined radiotherapy and chemotherapy and only 48% for the rest, who received no adjuvant therapy. Age of the patient has a definite influence on overall survival. We found significant statistical difference in survival between patients with total tumor resection and those with subtotal resection. The 5-year survival rate was not directly affected by tumor location, hydrocephalus or ventriculo-peritoneal shunting. Postoperative irradiation and chemotherapy are clearly associated with improved survival.


How to cite this article:
Sivasankaran A, Sgouros S, Walsh R, Hockley A. Medulloblastoma in children: Birmingham experience.J Pediatr Neurosci 2006;1:49-55


How to cite this URL:
Sivasankaran A, Sgouros S, Walsh R, Hockley A. Medulloblastoma in children: Birmingham experience. J Pediatr Neurosci [serial online] 2006 [cited 2020 Jun 6 ];1:49-55
Available from: http://www.pediatricneurosciences.com/article.asp?issn=1817-1745;year=2006;volume=1;issue=2;spage=49;epage=55;aulast=Sivasankaran;type=0