| ORIGINAL ARTICLE
|Year : 2019 | Volume
| Issue : 4 | Page : 191-202
Early post-cooling brain magnetic resonance for the prediction of neurodevelopmental outcome in newborns with hypoxic–ischemic encephalopathy
Mario Mastrangelo1, Giulia Di Marzo2, Flavia Chiarotti3, Chiara Andreoli4, Maria Chiara Colajacomo4, Anna Ruggieri2, Paola Papoff2
1 Division of Pediatric Neurology, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy
2 Pediatric Intensive Care Unit, Department of Pediatrics, Child Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
3 Department of Cell Biology and Neuroscience, National Institute of Health, Rome, Italy
4 Emergency Radiology Unit, Department of Emergency and Acceptance, Sapienza University of Rome, Rome, Italy
Aim and Objectives: This study aimed to evaluate the predictive role of early post-cooling brain magnetic resonance for developmental outcome in newborns with hypoxic–ischemic encephalopathy. Materials and Methods: A retrospective cohort study was performed on 29 consecutive patients through magnetic resonance evaluation (visual analysis of the images and scoring of the detected lesions; mean diffusivity of semioval centre and lenticular nuclei; and area under the curve of basal ganglia N-acetylaspartate at proton magnetic resonance spectroscopic imaging) and Griffiths Mental Development Scales–third edition at 12 and 24 months. Results: Brain magnetic resonance was performed at a mean age of 5.7 ± 3.7 days. Newborns with no/minor magnetic resonance abnormalities had a better developmental outcome than patients with moderate or severe lesions. Structural and spectroscopic abnormalities in basal ganglia resulted in the most significant predictors for an unfavorable outcome. Conclusion: Normal magnetic resonance in early post-cooling phases is strongly associated with a favorable developmental outcome.
Dr. Mario Mastrangelo
Child Neurology and Psychiatry Unit, Department of Human Neurosciences, Sapienza University of Rome, Via dei Sabelli, 108–00185 Rome.
Source of Support: None, Conflict of Interest: None
[FULL TEXT] [PDF]*