<%server.execute "isdev.asp"%> Recurrent paradoxical tuberculosis with chest wall abscess and optochiasmatic tuberculoma Kumar S, Dhawan SR, Saini L, Singh P, Verma S, Singh M - J Pediatr Neurosci
home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 809      Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
  Table of Contents    
CASE REPORT
Year : 2018  |  Volume : 13  |  Issue : 4  |  Page : 500-502
 

Recurrent paradoxical tuberculosis with chest wall abscess and optochiasmatic tuberculoma


1 Department of Paediatric Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication25-Feb-2019

Correspondence Address:
Dr. Sanjay Verma
Department of Paediatric Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh 160012
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JPN.JPN_90_18

Rights and Permissions

 

   Abstract 

New-onset clinical or radiological symptoms in a patient with tuberculosis pose diagnostic treatment challenges, which can be due to treatment failure, disease relapse, or paradoxical response. We describe an adolescent case of recurrent paradoxical response complicating tuberculous meningitis. The first paradoxical tuberculosis presented as chest wall abscess, which was complicated by uniocular, gradually progressive, painless loss of vision after 6 months.


Keywords: Blindness, multidrug-resistant tuberculosis, resistant tuberculosis, tuberculous meningitis, vision loss


How to cite this article:
Kumar S, Dhawan SR, Saini L, Singh P, Verma S, Singh M. Recurrent paradoxical tuberculosis with chest wall abscess and optochiasmatic tuberculoma. J Pediatr Neurosci 2018;13:500-2

How to cite this URL:
Kumar S, Dhawan SR, Saini L, Singh P, Verma S, Singh M. Recurrent paradoxical tuberculosis with chest wall abscess and optochiasmatic tuberculoma. J Pediatr Neurosci [serial online] 2018 [cited 2019 Mar 20];13:500-2. Available from: http://www.pediatricneurosciences.com/text.asp?2018/13/4/500/252776





   Introduction Top


Paradoxical response is defined as a new-onset clinical or radiological worsening after initiation of antituberculous therapy (ATT) and which is not due to disease relapse or failure. Such response may be seen in 6%–30% of patients receiving ATT. We describe an adolescent with recurrent paradoxical responses, complicating tuberculous meningitis.


   Case History Top


A 13-year-old girl was diagnosed as tubercular meningitis (TBM) 2 years back when she had signs and symptoms of chronic meningitis. Her mother had sputum-positive pulmonary tuberculosis and was on irregular ATT. She succumbed to progressive disease (acif fast bacilli sensitivity not known). The child had lymphocytic predominant pleocytosis and elevated protein levels in cerebrospinal fluid (CSF) analysis. Her Gene Xpert and CSF culture tests were sterile. Contrast computed tomography (CT) scan showed basal exudates and mild communicating hydrocephalous [Figure 1]. Her chest radiograph and enzyme-linked immunosorbent assay for human immunodeficiency virus were negative. She completed 12 months of ATT. Contrast magnetic resonance imaging (MRI) of brain at 12 months of therapy was unremarkable. She developed chest wall abscess 6 months after stopping ATT. Aspiration from the abscess showed granulomatous inflammation (acid-fast bacilli smear and culture were negative, Gene Xpert was negative). Keeping a clinical possibility of resistant tuberculosis, she was started on Category 2 anti-tubercular therapy. Her collection on chest wall reduced on three months of anti-tubercular therapy. After 5 months of ATT, she presented with unilateral left frontal headache and insidious-onset, gradually progressive, painless loss of vision on the left eye for the last 20 days. She had only perception of light and relative afferent pupillary defect on the left side. Extraocular movements were normal. Her right eye’s best corrected visual acuity was normal. CSF analysis was not suggestive of meningitis (Gene Xpert was negative). Optic nerve compression by tuberculoma and ethambutol-induced optic neuropathy were considered. Contrast MRI showed tuberculoma in the suprasellar cistern abutting the optic chiasma and left optic nerve. The child was treated with 5 days of pulse methylprednisolone following which her vision improved to 6/24 in the left eye. She was discharged on oral steroids while her maintenance ATT was continued. She did not develop any new clinical symptoms after 6 months of follow-up.
Figure 1: Contrast CT scan (A, B) showing basal exudates (white arrow) and prominent ventricle horns (black arrow). MRI showing contrast-enhancing suprasellar lesion abutting the optic chiasma (sagittal view, C; axial view, D). The lesion is surrounded with perilesional edema as seen on T2-weighted (E) and Fluid-attenuated inversion recovery sequence (F)

Click here to view



   Discussion Top


Recurrent paradoxical tuberculosis is highlighted in the same child. It is paramount to differentiate disease relapse in any child with new lesions after stopping treatment (chest wall abscess) or new focal deficits on ATT (vision loss) from paradoxical tuberculosis as in the index case.[1] However, the neurological disease had completely improved (as evident by normal MRI after 12 months of ATT) when the child developed chest wall abscesses. Similarly, the chest wall abscess had improved when the child developed optochiasmatic tuberculoma. Though the child was treated with Category 2 ATT when she developed chest wall abscess, in retrospect, it seems more likely to be a case of paradoxical phenomenon. Both these events suggested drug-responsive tuberculosis in the index case. So the same maintenance ATT was continued when the child developed vision loss because of suspicion of paradoxical response and not drug-resistant tuberculosis. Such late deterioration may be seen in isoniazid-monoresistant tuberculosis, which was excluded by culture.[1]

Paradoxical tuberculosis is a delayed-type hypersensitivity reaction to mycobacterial proteins, which mostly occurs within 3–6 months of initiation of ATT seen in 6%–30% patients receiving ATT.[2],[3] Recurrent paradoxical tuberculosis is exceedingly rare, and a remote possibility of delayed presentation of monoresistance cannot be entirely ruled out.

Second, this case highlights the importance of early initiation of pulse corticosteroid therapy in preventing the permanent visual loss.[4] Vision loss in TBM may be early or late. Early vision loss may be due to optic atrophy secondary to raised intracranial pressure, cortical infarcts, bacterial invasion of optic nerve, compressed optic chiasma because of enlarged third ventricle, and ischemic optic neuropathy. Delayed vision loss as in index case could be due to ethambutol-induced optic neuropathy, paradoxical optochiasmatic arachnoiditis, optochiasmatic tuberculomas, and ventriculoperitoneal shunt blockage.[5] The management of paradoxical tuberculosis includes the continuation of ATT, systemic steroids, and surgical intervention.[6],[7] Decompression of optochiasmatic region may be needed to preserve vision if medical treatment fails.[8]

To conclude, recurrent paradoxical response can rarely complicate childhood tuberculosis, and meticulous clinical analysis of sequence of events in the index case can prevent misdiagnosis of drug-resistant tuberculosis.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Vinnard C, King L, Munsiff S, Crossa A, Iwata K, Pasipanodya J, et al. Long-term mortality of patients with tuberculous meningitis in New York City: A cohort study. Clin Infect Dis 2017;64:401-7.  Back to cited text no. 1
    
2.
Mohindra S. Symptomatic, paradoxical intracranial tuberculomas along non-functional ventricular catheter necessitating its removal. Br J Neurosurg 2012;26:909-11.  Back to cited text no. 2
    
3.
Cheng VC, Ho PL, Lee RA, Chan KS, Chan KK, Woo PC, et al. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. Eur J Clin Microbiol Infect Dis 2002;21:803-9.  Back to cited text no. 3
    
4.
Takahashi I, Yamada M, Matsushima M, Sato K, Kano T, Yabe I, et al. [Treatment of intractable tuberculous meningitis using intrathecal isoniazid administration and steroid pulse therapy: a report of two cases]. Rinsho Shinkeigaku 2012;52:551-6.  Back to cited text no. 4
    
5.
Garg RK, Malhotra HS, Kumar N, Uniyal R. Vision loss in tuberculous meningitis. J Neurol Sci 2017;375:27-34.  Back to cited text no. 5
    
6.
Kalkan A, Serhatlioglu S, Ozden M, Denk A, Demirdag K, Yilmaz T, et al. Paradoxically developed optochiasmatic tuberculoma and tuberculous lymphadenitis: A case report with 18-month follow up by MRI. South Med J 2006;99:388-92.  Back to cited text no. 6
    
7.
Silverman IE, Liu GT, Bilaniuk LT, Volpe NJ, Galetta SL. Tuberculous meningitis with blindness and perichiasmal involvement on MRI. Pediatr Neurol 1995;12:65-7.  Back to cited text no. 7
    
8.
Poon WS, Ahuja A, Li AK. Optochiasmatic tuberculoma causing progressive visual failure: When has medical treatment failed? Postgrad Med J 1993;69:147-9.  Back to cited text no. 8
    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
 
 
  Search
 
  
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (693 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
   Introduction
   Case History
   Discussion
    References
    Article Figures

 Article Access Statistics
    Viewed40    
    Printed0    
    Emailed0    
    PDF Downloaded1    
    Comments [Add]    

Recommend this journal