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 CASE REPORT
Year : 2016  |  Volume : 11  |  Issue : 1  |  Page : 56-57

Juvenile amyotrophic lateral sclerosis: Classical wine glass sign on magnetic resonance imaging


Department of Radiodiagnosis, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Pallavi Aga
Type-4/87, SGPGIMS Campus, Raebareli Road, Lucknow, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.181251

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Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig disease, is a chronic degenerative neurologic disease and is characterized by the selective involvement of the motor system. Usually, patients present with upper motor neuron (UMN) and lower motor neuron compromise. Degeneration of the UMN in the cerebral cortex is one of the main pathologic changes in ALS. These changes usually affect corticospinal tracts leading to degeneration of the fibers which show characteristic hyperintensities along the tracts leading to the “wine glass sign.” Patients with ALS usually present in the sixth decade of life; presentation in pediatric age in the form of juvenile ALS being rare.






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