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 CASE REPORT
Year : 2015  |  Volume : 10  |  Issue : 2  |  Page : 178-180

Bilateral basal ganglia calcification and recurrent generalized seizures as initial presentation of idiopathic hypoparathyroidism in an infant


1 Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Jammu and Kashmir, India
2 Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India

Correspondence Address:
Manzoor Ahmad Bhat
Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.159209

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Pathological calcification of basal ganglia has been encountered in children since long back and is associated with various disease entities both acute and chronic. Idiopathic hypoparathyroidism is an important cause of basal ganglia calcification and can account for up to 73.8% of cases. The pathogenesis of basal ganglia calcification in hypoparathyroidism is not clear, however, a high calcium-phosphorus product and poor calcium control are believed to be directly related to calcification. Besides, a direct correlation is seen with the duration of hypocalcemia; the critical duration being ≥4 years. In the presented patient, basal ganglia calcification was seen at a very young age of 6 months. To best of our knowledge, this is probably the youngest case of bilateral basal ganglia calcification in idiopathic hypoparathyroidism in literature. This suggests that besides duration of hypocalcemia, certain genetic factors and the intrauterine milieu may have a role in the pathogenesis of basal ganglia calcification.






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