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CASE REPORT
Year : 2015  |  Volume : 10  |  Issue : 2  |  Page : 159-161
 

Giant parietal lobe infantile gliosarcoma in a 5-year-old child


Department of Neurosurgery, BYL Nair Hospital and T.N. Medical College, Mumbai, Maharashtra, India

Date of Web Publication22-Jun-2015

Correspondence Address:
Srikant Balasubramaniam
Department of Neurosurgery, BYL Nair Hospital, Mumbai Central, Mumbai 400 008, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.159194

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   Abstract 

The relative frequency of pediatric gliosarcoma (GSM) is 1.9% among glioblastomas and 0.5% among pediatric central nervous system tumors. A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days. Magnetic resonance imaging showed a large heterogeneously enhancing space occupying lesion in the left parieto-occipital region. A parieto-occipital craniotomy with radical excision of tumor was performed. The patient was given adjuvant therapy following surgery and survived until 9 months following surgery. The etiopathogenesis, treatment modalities and prognosis of GSM is discussed.


Keywords: Gliosarcoma in 5 year old, infantile gliosarcoma, posterior parietal gliosarcoma


How to cite this article:
Savant HV, Balasubramaniam S, Mahajan V. Giant parietal lobe infantile gliosarcoma in a 5-year-old child . J Pediatr Neurosci 2015;10:159-61

How to cite this URL:
Savant HV, Balasubramaniam S, Mahajan V. Giant parietal lobe infantile gliosarcoma in a 5-year-old child . J Pediatr Neurosci [serial online] 2015 [cited 2019 Jul 20];10:159-61. Available from: http://www.pediatricneurosciences.com/text.asp?2015/10/2/159/159194



   Introduction Top


Gliosarcoma (GSM) is a primary tumor of the brain composed of neoplastic glial cells in association with spindle celled sarcomatous elements. [1] It was first described by Stroebe but gained acceptance from detailed histological analyses of Feigin and Gross. [1],[2],[3] The 2007 World Health Organization classification scheme places primary GSM as a Grade 4 neoplasm and a variant of glioblastoma multiforme (GBM). [4] The relative frequency of pediatric GSM is 1.9% among glioblastomas and 0.5% among pediatric central nervous system tumors. [5] Ours is the second youngest case reported in literature and youngest with the lesion in the parieto-occipital region.


   Case Report Top


A 5-year-old female child came to us with history of fever and loss of appetite since 2 weeks and right sided weakness since 4 days. She had history of generalized convulsion 3 months back and one more focal convulsion in right sided limbs 4 days back followed by same side limb weakness. She was lethargic and had preference to sleep but was easily arousable. There was history of headache that was holocranial and with morning exacerbation. On examination, her right sided limb power was 4/5. There was hypertonia and exaggerated reflexes in right sided limbs. Magnetic resonance imaging (MRI) showed a large heterogeneously enhancing space occupying lesion in the left parieto-occipital region causing significant mass effect and midline shift. The lesion was partly solid and partly cystic with rim enhancement and in close proximity to the occipital horn of the lateral ventricle [Figure 1] and [Figure 2].

The patient was operated in right lateral position. A parieto-occipital craniotomy was performed, and the brain was found to be extremely tense. A small cortisectomy was done in the posterior parietal region and tumor identified [Figure 3]. The tumor was grayish in color, firm in consistency and had a good plane of cleavage from surrounding brain parenchyma. The lesion was excised completely in piecemeal fashion. The choroid plexus with ependyma was found adherent to the capsule that was preserved. Histopathology was suggestive of the malignant spindle cell tumor with densely packed tumor cells. Immunohistochemistry (IHC) was performed which was IHC-negative for glial fibrillary acidic protein and S-100. MIB-1 labeling index at some areas was up to 40%.
Figure 1: The postcontrast axial image showing the large lesion in the left parieto-occipital region with peripheral contrast enhancement

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Figure 2: The postcontrast coronal image showing the lesion with mass effect and displacement of the lateral ventricle

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Figure 3: The small cortisectomy through which piecemeal excision of the tumor was performed

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Postoperatively patient improved in sensorium and right sided limb power. The power was Grade 5/5 by postoperative day 1. The wound healed well and suture removal was done on day 9. Postoperative MRI done was suggestive of complete excision of tumor [Figure 4]. The patient underwent concurrent chemoradiation of 60 Gy along with temozolomide 75 mg/m 2 on all days of radiation. The patient had headache and lethargy on postoperative day 15 for which a repeat imaging was done which showed hydrocephalus. We performed a ventriculoperitoneal shunt [Figure 5]. The patient improved following the cerebrospinal fluid diversion procedure. The patient was asymptomatic at 6 months followup. At 9 months following surgery, she got readmitted with drowsiness, decerebration, and respiratory tract infection. She expired even before repeat imaging could be done.
Figure 4: Complete excision of the tumor with residual enhancement of the choroid plexus of the ventricle

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Figure 5: Enlarged ventricles with ventriculoperitoneal shunt in situ

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   Discussion Top


Gliosarcomas are rare and have an incidence of 1.8-2.8% of that of GBMs. [6],[7] The diagnosis of GSM should be made when a tumor contains an admixture of two distinctive neoplastic tissues. One is an anaplastic astrocytoma, and the other resembles a fibrosarcoma. [3],[8] Certain authors have suggested a presence of at least one atypical mesenchymal cell proliferation in one confluent medium power (×10 objective with ×10 eyepiece) field for a diagnosis of GSM. [9] Atypical components such as osteochondroma or osteosarcoma have been described in GSM. [10],[11]

There are two theories explaining the pathogenesis of GSM. Earlier theory suggested that the sarcomatous component originates from neoplastic transformation of hyperplastic blood vessels found in high-grade glioma. [2] The newer theory suggests monoclonal origin of both components of GSM with sarcomatous component originating via aberrant mesenchymal differentiation of the malignant glioma. This theory explains the absence of significant difference in clinical outcome between glioblastoma and GSM. [12] GSM has also been described following radiotherapy (RT). [5],[9]

Even though several studies have showed no significant differences between GSM and GBM with regard to age, sex, size, clinical presentation, and median survival, they have been established to be two different pathologies. [3],[12],[13] Some studies showed a temporal lobe predilection for GSM whereas others found no such difference. [3],[7],[9],[12],[13] The youngest case in literature of a 4-year-old child also showed tumor in the temporal lobe. [14] [Table 1] shows the comparison of the other infantile GSM with our case. There have been anecdotal reports of the neoplasm in varied locations such as posterior fossa. [15] Few studies have also found that GSM tends to be smaller at presentation as compared to GBM. [9] In spite of these similarities, the two pathologies differ on intraoperative appearance (GSM similar to meningioma due to its well-circumscribed nature), tendency for extraneural metastasis and infrequency of epidermal growth factor receptor mutations. [3],[12],[13]

Gliosarcoma most commonly affects adults in the sixth or seventh decade of life and more commonly men (male: female ratio of 1.4-1.8:1). [6],[13] A total of 24 cases of pediatric GSMs have been reported in the literature with a median age of 11 years with an increased incidence following exposure to RT. [5] The presenting signs and symptoms are consistent with those of expanding space occupying lesion such as headache, hemiparesis, seizures, and cognitive decline. [12]
Table 1: Comparision of the two youngest cases of gliosarcoma reported in literature

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Treatment modalities for GSM include tumor resection, postoperative RT and chemotherapy. [12] The median survival among all GSM patients has been reported to be 9 months; however, there are some variables that alter this. [13] Patients diagnosed prior to 50 years had a higher median survival period of 15 months as compared to 7 months for those diagnosed after age 50. Radical excision prolonged survival to 7-11 months as compared to 4 months with biopsy alone. RT increased the survival rate from 4 months to 10 months. [13] The role of chemotherapy is still uncertain with a few encouraging reports. [12]


   Conclusion Top


Although gliosarcomas occur most commonly in the sixth or seventh decade and have a temporal lobe predilection, they can occur in any age group or any region. They should be considered in the differential diagnosis of all space occupying lesions. More dedicated studies are needed to understand the true nature of these biphasic tumors.

 
   References Top

1.
Stroebe H. Uber Entstehung und Bau der Gehirngliome. Beitr Pathol Anat Allg Pathol 1895;18:405-86.  Back to cited text no. 1
    
2.
Feigin IH, Gross SW. Sarcoma arising in glioblastoma of the brain. Am J Pathol 1955;31:633-53.  Back to cited text no. 2
    
3.
Morantz RA, Feigin I, Ransohoff J 3 rd . Clinical and pathological study of 24 cases of gliosarcoma. J Neurosurg 1976;45:398-408.  Back to cited text no. 3
    
4.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.  Back to cited text no. 4
    
5.
Ravisankar S, Chander RV, Devadoss PK. Pediatric gliosarcoma with fibrosarcomatous differentiation: Report of a rare case. Indian J Pathol Microbiol 2012;55:521-4.  Back to cited text no. 5
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6.
Lutterbach J, Guttenberger R, Pagenstecher A. Gliosarcoma: A clinical study. Radiother Oncol 2001;61:57-64.  Back to cited text no. 6
    
7.
Parekh HC, O'Donovan DG, Sharma RR, Keogh AJ. Primary cerebral gliosarcoma: Report of 17 cases. Br J Neurosurg 1995;9:171-8.  Back to cited text no. 7
    
8.
Sarkar C, Sharma MC, Sudha K, Gaikwad S, Varma A. A clinico-pathological study of 29 cases of gliosarcoma with special reference to two unique variants. Indian J Med Res 1997;106:229-35.  Back to cited text no. 8
    
9.
Meis JM, Martz KL, Nelson JS. Mixed glioblastoma multiforme and sarcoma. A clinicopathologic study of 26 radiation therapy oncology group cases. Cancer 1991;67:2342-9.  Back to cited text no. 9
    
10.
Khan EM, Pandey R, Gupta S, Mittal P. Gliosarcomas: Pathological spectrum. Indian J Cancer 1994;31:118-23.  Back to cited text no. 10
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11.
Li N, Qian Y, Ma H. A clinical and pathological study of gliosarcoma. Zhonghua Bing Li Xue Za Zhi 1996;25:129-31.  Back to cited text no. 11
    
12.
Han SJ, Yang I, Tihan T, Prados MD, Parsa AT. Primary gliosarcoma: Key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity. J Neurooncol 2010;96:313-20.  Back to cited text no. 12
    
13.
Kozak KR, Mahadevan A, Moody JS. Adult gliosarcoma: Epidemiology, natural history, and factors associated with outcome. Neuro Oncol 2009;11:183-91.  Back to cited text no. 13
    
14.
Melo JR, Souza AL, Reis RC, Almeida MA. Infantile gliosarcoma. Arq Neuropsiquiatr 2008;66:88-9.  Back to cited text no. 14
    
15.
Balasubramaniam S, Tyagi DK, Sawant HV, Epari S. Posterior fossa involvement in a recurrent gliosarcoma. J Neurosci Rural Pract 2012;3:60-4.  Back to cited text no. 15
[PUBMED]  Medknow Journal  


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
 
 
    Tables

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