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 CASE REPORT
Year : 2015  |  Volume : 10  |  Issue : 2  |  Page : 143-145

A rare case of glycine encephalopathy unveiled by valproate therapy


1 Department of Paediatric Neurology, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu, India
2 Department of Biochemistry, Institute of Child Health, Madras Medical College, Chennai, Tamil Nadu, India
3 Intern, Stanley Medical College, Chennai, Tamil Nadu, India
4 Department of Paediatrics, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Velusamy Subramanian
Department of Paediatric Neurology, Institute of Social Paediatrics, Stanley Medical College, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.159200

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Glycine encephalopathy (GE) or nonketotic hyperglycinemia is an autosomal recessive disorder due to a primary defect in glycine cleavage enzyme system. It is characterized by elevated levels of glycine in plasma and cerebrospinal fluid usually presenting with seizures, hypotonia, and developmental delay. In our case, paradoxical increase in seizure frequency on starting sodium valproate led us to diagnose GE.






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