<%server.execute "isdev.asp"%> Quadrigeminal plate cistern lipoma presenting with seizures in a child Jha A, Khalid M, Gupta P, Gupta G, Zaidi SY - J Pediatr Neurosci
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LETTER TO THE EDITOR
Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 172-173
 

Quadrigeminal plate cistern lipoma presenting with seizures in a child


1 Department of Radiodiagnosis, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
2 Department of General Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
3 Department of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Date of Web Publication7-Sep-2013

Correspondence Address:
Abhishek Jha
C/O defender Locks and Hardware, Achal Tank, Aligarh 202 001, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.117865

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How to cite this article:
Jha A, Khalid M, Gupta P, Gupta G, Zaidi SY. Quadrigeminal plate cistern lipoma presenting with seizures in a child . J Pediatr Neurosci 2013;8:172-3

How to cite this URL:
Jha A, Khalid M, Gupta P, Gupta G, Zaidi SY. Quadrigeminal plate cistern lipoma presenting with seizures in a child . J Pediatr Neurosci [serial online] 2013 [cited 2019 Apr 20];8:172-3. Available from: http://www.pediatricneurosciences.com/text.asp?2013/8/2/172/117865


Intracranial lipomas are neither hamartomatous nor neoplastic lesions. They result from abnormal persistence and development of meninx primitiva. [1] They are extremely rare and are seen in around 0.08-0.2% of all autopsy cases and constitute only 0.06-0.3% of incidental lesions. [2] Rarely, they have been associated with seizures, headache, and behavioral disturbances. [3] These lesions are managed conservatively owing to their indolent course.

A 3-year-old child from rural background was referred for CT scan of head for evaluation of single episode of generalized tonic-clonic seizures 1 day back. There was associated loss of consciousness and postictal confusion. The patient denied any history of prior similar episodes, and his neurological development was normal. On examination, the patient was in overall good general health and systemic examination of respiratory, cardiovascular, and nervous system revealed no anomaly. Routine hematological investigations were within normal limits.

Axial non-contrast CT scan of the head revealed a well-defined lobulated hypodense lesion, with smooth margins and showing fat attenuation (CT value of -30 HU), in the quadrigeminal plate cistern [Figure 1]. There was no evidence of calcification within the lesion, and the lesion exhibited no enhancement on contrast administration. No other abnormality was detected.
Figure 1: (a) Axial non-contrast CT scan of the patient showing a well-defined lobulated hypodense lesion, with no evidence of calcification and showing smooth margins and fat attenuation, in the quadrigeminal plate cistern. (b) On contrast administration, there is no enhancement of the lesion

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A provisional diagnosis of quadrigeminal plate lipoma was made, and patient was treated with oral anti-epileptic drugs. The patient is on regular follow up for 1 year, with no evidence of progression of symptoms.

Meckel was the first to report intracranial lipomas, way back in 1818. [1] Since then, intracranial lipomas have being routinely described in literature as incidental lesions. Yilmaz et al. reported that these lesions were occasionally associated with headache, epilepsy, and neurological dysfunction. [3] Lipomas of the quadrigeminal plate have been associated with obstructive hydrocephalus due to compression of cerebral aqueduct. [4] These lesions are usually seen in children and young adults, but to the best of our knowledge, this is the youngest case of a child with quadrigeminal plate cistern lipoma.

The most common location of these lesions is pericallosal, where 45% of these lesions are found. Other uncommon locations include suprasellar cistern, quadrigeminal plate cistern, cerebellopontine angle, and the sylvian fissure. On CT scans, they appear as well demarcated non-enhancing lesions with fat attenuation. The lesions in pericallosal location may show calcifications. On MRI, they appear hyperintense on both T1W and T2W sequences and show signal drop on fat saturated images. The common differentials of these lesions on imaging include dermoid and epidermoid cysts, tectal plate cysts, arachnoid cysts and, rarely, lipomatous transformation of neoplasms like DNET and tectal gliomas.

An association of these lesions has been described with neurocutaneous syndromes like encephalocraniocutaneous lipomatosis, epidermal nevus syndrome, or congenital infiltrating lipomatosis. [5] Quadrigmenial plate lipomas have also been associated with hypoplasia of inferior colliculus. Vascular abnormalities including kinking and narrowing along with arteriovenous malformations have also been linked with intracranial lipomas. [6]

These lesions are usually managed conservatively [7] as surgical removal of these lesions is difficult owing to their close contiguity with adjacent neurovascular structures. Attempts of surgical evacuation often result in marked neurological deterioration. [8] In conclusion, quadrigeminal plate lipomas are extremely rare entities with varied clinical presentations. A thorough knowledge of the imaging features is essential to rule out other conditions as it is usually asymptomatic and rarely requires aggressive management.

 
   References Top

1.Truwit CL, Barkovich AJ. Pathogenesis of intracranial lipoma: An MR study in 42 patients. AJR Am J Roentgenol 1990;155:855-65.  Back to cited text no. 1
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2.J Fandino, J bermudes. Lipoma de la cisterna cuadrigemina y de la cisura calcarina: Caso clinico y revision de la literatura. Neurocirugia 2005;16:173-6.  Back to cited text no. 2
    
3.Yilmaz N, Unal O, Kiymaz N, Yilmaz C, Etlik O. Intracranial lipomas: A clinical study. Clin Neurol Neurosurg 2006;108:363-8.  Back to cited text no. 3
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4.Nikaido Y, Imanishi M, Monobe T. Lipoma in the quadrigeminal cistern: Case report. Neurol Med Chir (Tokyo) 1995;35:175-8.  Back to cited text no. 4
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5.Canyigit M, Oguz KK. Epidermal nevus syndrome with internal carotid artery occlusion and intracranial and orbital lipomas. AJNR Am J Neuroradiol 2006;27:1559-61.  Back to cited text no. 5
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6.Warakaulle DR, Anslow P. Differential diagnosis of intracranial lesions with high signal on T1 or low signal on T2-weighted MRI. Clin Radiol 2003;58:922-33.  Back to cited text no. 6
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7.Saatci I, Aslan C, Renda Y, Besim A. Parietal lipoma associated with cortical dysplasia and abnormal vasculature: Case report and review of the literature. AJNR Am J Neuroradiol 2000;21:1718-21.  Back to cited text no. 7
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8.Gastaut H, Regis H, Gastaut JL, Yermenos E, Low MD. Lipomas of the corpus callosum and epilepsy. Neurology 1980;30:132-8.  Back to cited text no. 8
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