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CASE REPORT
Year : 2012  |  Volume : 7  |  Issue : 1  |  Page : 40-42
 

Management problems in a case of third ventricular choroid plexus papilloma


Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication28-Jun-2012

Correspondence Address:
Sandeep Mohindra
Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.97622

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   Abstract 

A rare case of third ventricular choroid plexus papilloma and associated complication of shunt ascites is described. We propose to convert shunt into ventricular drain in such a situation and reassess the requirement of shunt after complete tumor removal.


Keywords: Choroid plexus papilloma, hydrocephalus, shunt ascites


How to cite this article:
Mohindra S, Savardekar A. Management problems in a case of third ventricular choroid plexus papilloma. J Pediatr Neurosci 2012;7:40-2

How to cite this URL:
Mohindra S, Savardekar A. Management problems in a case of third ventricular choroid plexus papilloma. J Pediatr Neurosci [serial online] 2012 [cited 2019 Apr 25];7:40-2. Available from: http://www.pediatricneurosciences.com/text.asp?2012/7/1/40/97622



   Introduction Top


Choroid plexus neoplasms constitute about 0.5% of all intracranial neoplasms. Among these, third ventricular papillomas are rare occurrence, while majority are found in lateral ventricles. [1],[2] Most of these neoplasms are benign papillomas, while one-fifth are malignant carcinomas. In contrast to lateral ventricular choroid plexus papillomas (CPPs), third ventricular CPPs pose unique management challenges in addition to problems inherent to their difficult anatomical location. [3]

The present communication describes a rare case of a large third ventricular CPP, its radiological findings, and management problems and describes all reported management problems reported in the literature.


   Case Report Top


A 7-month-old infant, born of full-term normal vaginal delivery, with normal developmental milestones, presented with complaints of poor feeding, lethargy, and altered sensorium for a weeks duration. There was history of increasing head size for the last 1 month. During examination, the child was crying, with no eye contact. Anterior fontanella was tense and bulging, with dilated veins shining on both temporal bones. Lateral gaze palsy and brisk deep tendon reflexes of knee joints were noted.

A computerized tomography (CT) scan of head showed a mass lesion arising within the third ventricle, extending into both the lateral ventricles, with gross hydrocephalus. Magnetic resonance imaging (MRI) scan revealed similar findings and the antero-posterior extent of the tumor was well defined. There was intense contrast uptake by the tumor, on contrast administered MRI scans [Figure 1].
Figure 1: (a) Axial section T1 weighted MRI scan showing a third ventricular mass lesion. (b) Axial section of contrast enhanced T1 weighted MRI scan showing a large third ventricular mass lesion which enhances brilliantly. (c) Sagittal section of the same patient. (d) Coronal section of MRI scan showing a third ventricular lesion. (e) Axial section of T2 weighted scan. (f) Axial section of follow-up scan showing total excision of the tumor

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The infant underwent right-sided ventriculoperitoneal shunt. After initial improvement, on the seventh postshunt day, infant developed irritability and gross abdominal distension, with bulging fontenala. Abdominal ultrasonography suggested gross ascites. The lower end of the shunt tip was exteriorized and was maintained as ventricular drain so as to relieve intracranial and intra-abdominal pressures. Draining shunt tip was kept at the height of 10 cm of water, which continued to drain 800-1000 ml of CSF daily. Serum electrolytes were strictly monitored during the drainage period. On the 14th postshunt day, definitive surgery was performed through the left frontal craniotomy and trans-sulcal (trans-cortical route) approach. Complete excision of the soft, suckable, moderately vascular tumor was achieved. The ventricular part of the tumor was delivered into the left lateral ventricle through foramen of Monro which was grossly dilated to 5 cm. Immediately after surgery, the CSF drainage had decreased to near normal levels (15-20 ml/hour) and the exteriorized shunt could be removed on the second postoperative day. On the 10th postoperative day, the child was playful, accepting oral feeds, depressed fontanella, and good eye-contact. Postoperative CT scan showed no residual tumor or hydrocephalus. The histopathology of the excised tumor suggested choroid plexus papilloma. At 6 months of follow-up, MRI scans revealed totally excised tumor, with mild ventriculomegaly, but the child remains asymptomatic, with no bulging of fontanella.


   Discussion Top


Choroid plexus papillomas (CPPs) are congenital intracranial tumors of neuro-ectodermal origin. They are most common in lateral ventricle, sometimes multiple, and rarely occur in third ventricle. [1] Inherent to their location, third ventricular CPPs pose difficult management problems [Table 1]. [3] Smaller tumors are difficult to detect and further, difficult to excise. [4] Larger tumors tend to widen foramen of Monro, thereby spilling over into lateral ventricle, making surgical extirpation easy. Henceforth, larger tumors are surgically easily excisable via trans-ventricular route.
Table 1: Management problems in pediatric third ventricular choroid plexus papillomas

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Shunt ascites is a common management problem inherent to CPPs, reported frequently in the literature. [5],[6] The normal CSF production (0.29-0.35 ml/min) was increased to 0.63 ml/min as these neoplasms continue to maintain normal physiological functions and are detected early in life, these are congenital in origin. The present case had 900--1000 ml/day of CSF output. However, older patients harboring such tumors are on records.

Excessive bleeding during tumor resection may herald successful total surgical resection. [3] This occurs due to hyper-vascular tumor, inability to reach at the feeding vessels due to tumor bulk, and very less blood volume reserve in pediatric patients. Superselective embolization has been described, but similar successful attempts have not been duplicated. [3]

Shunt ascites is a rare complication of CSF shunting surgery. [5],[6] Such a complication due to CSF overproduction and CSF ascites may occur due to choroid plexus hypertrophy and other benign tumors, for example optic-hypothalamic glioma in infancy and childhood. Shunt ascites may occur within a few days to many months after shunt insertion, depending upon the amount of CSF production and peritoneal absorption capacity. It appears that younger children tend to develop ascites earlier owing to lesser absorptive surface. The management involves exteriorization and revision of shunt catheter or conversion to VA shunt. [5],[6],[7]

It is interesting that the CSF dysbalance due to overproduction can be addressed if tumor hypertrophied CP excision is undertaken early in the course. If delay occurs in the removal of the lesion, the patient can be converted to shunt dependent within months of shunting. This can occur in the absence of hemorrhage, infection or metastatic spread that might cause CSF pathway obstruction secondarily. The reasons for the development of shunt dependence are not known. We propose that total tumor excision should be attempted after shunt exteriorization and then reassessed for shunt requirement. We agree that subarachnoid block continue to exist as a cause of hydrocephalus, but a significant number of patients may get rid of shunt systems for their entire lives.


   Conclusion Top


CPPs of third ventricle pose a difficult challenge due to their anatomical location and involvement of pediatric population. Shunt ascites in such cases is mainly attributed to overproduction of CSF and the management should best be tailored to attack the tumor, thereby avoiding the CSF shunting device, if possible.

 
   References Top

1.Carson BS, Weingart JD, Guarnieri M, Fisher PG. Third ventricular choroid plexus papilloma with psychosis. Case report. J Neurosurg 1997;87:103-5.  Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Schijman E, Monges J, Raimondi AJ, Tomita T. Choroid plexus papillomas of the III ventricle in childhood. Their diagnosis and surgical management. Childs Nerv Syst 1990;6:331-4.  Back to cited text no. 2
[PUBMED]    
3.Do HM, Marx WF, Khanam H, Jensen ME. Choroid plexus papilloma of the third ventricle: Angiography, preoperative embolization, and histology. Neuroradiology 2001;43:503-6.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4.Nakano I, Kondo A, Iwasaki K. Choroid plexus papilloma in the posterior third ventricle: Case report. Neurosurgery 1997;40:1279-82.  Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.Kumar R, Sahay S, Gaur B, Singh V. Ascites in ventriculoperitoneal shunt. Indian J Pediatr 2003;70:859-64.  Back to cited text no. 5
[PUBMED]    
6.Pawar SJ, Sharma RR, Mahapatra AK, Lad SD, Musa MM. Choroid plexus papilloma of the posterior third ventricle during infancy & childhood: Report of two cases with management morbidities. Neurol India 2003;51:379-82.  Back to cited text no. 6
[PUBMED]  Medknow Journal  
7.Pianetti Filho G, Fonseca LF, da Silva MC. Choroid plexus papilloma and Aicardi syndrome: Case report. Arq Neuropsiquiatr 2003;60:1008-10.  Back to cited text no. 7
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]


This article has been cited by
1 Choroid plexus papilloma of the third ventricle: A rare infantile brain tumor
Gupta, P., Sodhi, K.S., Mohindra, S., Das, A., Khandelwal, N.
Journal of Pediatric Neurosciences. 2013; 8(3): 247-249
[Pubmed]



 

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