<%server.execute "isdev.asp"%> Catastrophic brain metastatic lesions in a child with cutaneous melanoma Vide AT, Marques AM, Reis C - J Pediatr Neurosci
home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 860      Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
  Table of Contents    
LETTER TO THE EDITOR
Year : 2011  |  Volume : 6  |  Issue : 2  |  Page : 170-171
 

Catastrophic brain metastatic lesions in a child with cutaneous melanoma


Department of Neuroradiology, Centro Hospitalar So Joo, EPE, Porto, Portugal

Date of Web Publication13-Feb-2012

Correspondence Address:
Ana Teresa Vide
Department of Neuroradiology, Centro Hospitalar So Joo, EPE, Porto
Portugal
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.92868

Rights and Permissions

 



How to cite this article:
Vide AT, Marques AM, Reis C. Catastrophic brain metastatic lesions in a child with cutaneous melanoma. J Pediatr Neurosci 2011;6:170-1

How to cite this URL:
Vide AT, Marques AM, Reis C. Catastrophic brain metastatic lesions in a child with cutaneous melanoma. J Pediatr Neurosci [serial online] 2011 [cited 2019 Jul 18];6:170-1. Available from: http://www.pediatricneurosciences.com/text.asp?2011/6/2/170/92868


Dear Sir,

Melanoma is very rare in children, accounting for only 1-3% of the malignant tumors in this age group; only 0.3-0.5% have developed in prepubertal children. [1]

Richardson et al. divided melanoma into congenital; infantile; childhood; and adolescent melanoma. [2]

The role of sunlight in the development of melanoma is well established. Other predisposing conditions include latitude, skin type, pigmentation, family history, and melanoma susceptibility genes (CDKN2A and CDK4). [1]

MRI findings of melanoma vary according to the histology of the tumor. The typical melanotic pattern presents hyperintensity on T1-weighted images, hypointensity on T2-weighted images, and iso/hyperintensity on proton density-weighted images in relation to cortex, and the amelanotic pattern manifests as hypo/isointense on T1 and hyper/isointense on T2-weighted images, compared to the cortex. [3],[4]

We present a rare case of exuberant and catastrophic brain metastatic lesions, predominantly with amelanotic pattern on MRI, that occurred early during the course of his disease.

A 14-year-old caucasian boy was admitted to the hospital due to an ulcerated nevus in the left ear that started bleeding one week before. The lesion was ulcerated, with irregular shape and measuring approximately 2 × 2 cm. The remaining physical exam was normal.

An excisional biopsy was performed and pathological findings indicated a superficial spreading melanoma, Clark level IV (invasion of reticular dermis), and Breslow's tumor thickness was 2.5 mm. Furthermore, wide excision including a 2.5 cm normal skin margins from the previous incision line was performed, along with biopsy of a newly diagnosed sentinel nodule. The node was positive, demanding left cervical radical neck dissection, which revealed regional metastatic spread.

On the second month follow-up, physical examination depicted a painful left cervical mass which showed to be melanoma metastasis. Adjuvant radiotherapy was performed (50 Gy/25), twice a week. Six months later, he was admitted with symptoms of intracranial hypertension, presenting dilated and poorly reactive pupils.

Brain MRI in a 3 Tesla Siemens equipment revealed numerous supra- and infratentorial lesions, the majority of them round and regular shaped, measuring between 5 and 25 mm. The majority of the lesions were hypo/isointense in T1-weighted images and hyper/isointense in T2-weighted in relation to cortex, and some presented spontaneous high signal in the T1-weighted images, the larger one in the left frontal region. Nodular enhancing pattern was seen after gadolinium administration [Figure 1]. There was considerable perilesional edema contributing to local mass effect and compression of 4 th ventricle/cerebral aqueduct resulting in hydrocephaly but with no interstitial edema. Also noted intraventricular lesion in the third ventricle and one left parietal skull lesion. The patient died 1 month later.
Figure 1: Axial T1 weighted MR image postgadolinium (TR/TE, 512/12). Numerous supra and infratentorial round lesions, with nodular and homogeneous pattern of enhancement. Also note the enlargement of the temporal horns of the lateral ventricles, without interstitial edema

Click here to view


Melanoma is rarely seen during childhood and therefore little information is available about clinical and biological features of the tumor in this age group. [1]

In the study of Rodriguez-Galino et al., including 44 children diagnosed with melanoma, around 18% developed brain metastases during the course of their disease, with a median time of presentation of 20 months after diagnosis; [5] however in the present case brain metastases occurred in the first 6 months after diagnosis much earlier than expected.

There is no clear consensus as to whether the appearance of melanoma is due primarily to the paramagnetic effects of blood products, melanin or both, and it is likely due to variable contributions from both. [3],[4]

We present a case of severe manifestation of brain metastases of cutaneous melanoma with multiple supra and infratentorial lesions, predominantly with amelanotic pattern, along with intraventricular and skull metastases. As cutaneous melanoma is very rare in children, high level of suspicion is necessary to make an early diagnosis, which is crucial to the outcome of the disease.

 
   References Top

1.Ferrari A, Bono A, Baldi M, Collini P, Casanova M, Pennacchioli E, et al. Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution. Pediatrics 2005;115:649-54.  Back to cited text no. 1
    
2.Richardson SK, Tannous ZS, Mihm MC. Congenital and infantile melanoma: Review of the literature and report of an uncommon variant, pigment-synthesizing melanoma. J Am Acad Dermatol 2002;47:77-90.  Back to cited text no. 2
    
3.Isiklar I, Leeds N, Fuller G, Kumar A. Intracranial metastatic melanoma: Correlation between MR imaging characteristics and melanin content. AJR Am J Roentgenol 1995;165:1503-12.  Back to cited text no. 3
    
4.Escott E. A variety of appearances of malignant melanoma in the head: A review. RadioGraphics 2001;21:625-39.  Back to cited text no. 4
    
5.Rodriguez-Galino C, Pappo A, Kaste S, Rao B, Caln A, Jenkins J, et al. Brain metastases in children with melanoma. Cancer 1997;79:2440-5.  Back to cited text no. 5
    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
 
 
  Search
 
  
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (303 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    References
    Article Figures

 Article Access Statistics
    Viewed2124    
    Printed55    
    Emailed0    
    PDF Downloaded90    
    Comments [Add]    

Recommend this journal