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  Table of Contents    
LETTER TO THE EDITOR
Year : 2011  |  Volume : 6  |  Issue : 2  |  Page : 163-164
 

Response


Department of Pediatrics, Neonatal Services Division, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, University of Health Sciences, Rohtak, Haryana, India

Date of Web Publication13-Feb-2012

Correspondence Address:
Geeta Gathwala
6J/8, Medical Enclave, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak - 124 001, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.92862

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How to cite this article:
Gathwala G, Khera A, Singh J. Response. J Pediatr Neurosci 2011;6:163-4

How to cite this URL:
Gathwala G, Khera A, Singh J. Response. J Pediatr Neurosci [serial online] 2011 [cited 2019 Apr 22];6:163-4. Available from: http://www.pediatricneurosciences.com/text.asp?2011/6/2/163/92862


Thank you for your comments [1] and interest in the article. [2] Severity of Asphyxia, whatever the cause, is the most important determinant for the outcome of asphyxia.

Magnesium has been studied rather well in the treatment of Persistent Pulmonary Hypertension in a newborn and there are several reports on its safety in severe asphyxia, including one by us. [3],[4],[5],[6]

Certainly magnesium given to the mother crosses the placenta and is likely to affect the fetus. Magnesium has been used in the treatment of pregnancy-induced hypertension (PIH) in the mother for long, and reportedly, the asphyxiated infants of these mothers had a more favorable outcome than those with no Mg. It is a good suggestion to study the outcome of asphyxia in neonates where Mg has been administered to the mothers. A randomized controlled trial (RCT) that studied the effect of magnesium sulfate given for neuroprotection before preterm birth, reported an improvement in the neurological outcome, with reduced rates of cerebral palsy. [7]

 
   References Top

1.Wiwanitkit S, Wiwanitkit V. Magnesium for neuroprotection. J Pediatr Neurosci 2011;6:162-3.  Back to cited text no. 1
    
2.Gathwala G, Khera A, Singh I. Magnesium therapy in birth asphyxia. Indian J Pediatr 2006;73:209-12.  Back to cited text no. 2
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3.Levene M, Blennow M, Whitelaw A, Hankø E, Fellman V, Hartley R. Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia. Arch Dis Child Fetal Neonatal Ed 1995;73:F174-7.  Back to cited text no. 3
    
4.Ichiba H, Tamai H, Negishi H, Ueda T, Kim TJ, Sumida Y, et al. RCT of Mg SO4 infusion for Severe birth Asphyxia. Pediatr Int 2002;44;505-9.  Back to cited text no. 4
    
5.Bhat MA, Charoo BA, Bhat JI, Ahmad SM, Ali SW, Mufti MU. Magnesium in severe perinatal Asphyxia: A randomised placebo controlled trial. Pediatrics 2009;123:e764-9.  Back to cited text no. 5
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6.Gathwala G, Khera A, Singh I. Magnesium therapy in birth asphyxia. Indian J Pediatr 2006;73:209-12.  Back to cited text no. 6
[PUBMED]    
7.Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, et al. A RCT of MgSO4 for prevention of cerebral palsy. N Engl J Med 2008;359:895-905.  Back to cited text no. 7
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