<%server.execute "isdev.asp"%> Childhood steroid-responsive ophthalmoplegic migraine Roy M, Ghosh J, Deb S, Pandit N - J Pediatr Neurosci
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CASE REPORT
Year : 2011  |  Volume : 6  |  Issue : 1  |  Page : 69-71
 

Childhood steroid-responsive ophthalmoplegic migraine


1 Department of Pediatric Medicine, North Bengal Medical College and Hospital, Darjeeling, India
2 Department of Pediatric Medicine, SSKM and IPGMER, Kolkata, India
3 Department of Neuro-Medicine, North Bengal Medical College and Hospital, Darjeeling, India
4 Department of Radio-diagnosis, North Bengal Medical College and Hospital, Darjeeling, India

Date of Web Publication2-Sep-2011

Correspondence Address:
Mahua Roy
931, Jawpur Road, Kolkata - 700074
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.84414

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   Abstract 

Ophthalmoplegic migraine (OM) is characterized by recurrent attacks of headache with paresis of ocular cranial nerves. Previously, it was classified as a variant of migraine, but recently, International Headache Classification (IHCD-II) has reclassified OM to the category of neuralgia. Presently, OM is considered a type of recurrent demyelinating cranial neuropathy. We report an adolescent girl with OM, who had been treated with steroid and showed dramatic improvement.


Keywords: Demyelinating cranial neuropathy, migraine, neuralgia, ophthalmoplegia


How to cite this article:
Roy M, Ghosh J, Deb S, Pandit N. Childhood steroid-responsive ophthalmoplegic migraine. J Pediatr Neurosci 2011;6:69-71

How to cite this URL:
Roy M, Ghosh J, Deb S, Pandit N. Childhood steroid-responsive ophthalmoplegic migraine. J Pediatr Neurosci [serial online] 2011 [cited 2019 Jun 25];6:69-71. Available from: http://www.pediatricneurosciences.com/text.asp?2011/6/1/69/84414



   Introduction Top


Ophthalmoplegic migraine (OM) is characterized by recurrent attacks of migrainous headache, associated with paresis of one or more ocular cranial nerves with absence of demonstrable intracranial lesions, other than Magnetic Resonance Imaging (MRI) of the brain changes within the affected nerve. From the recent observations, it has been considered to be a type of recurrent demyelinating cranial neuropathy. International Headache Classification (IHCD-II) has reclassified OM from a variant of migraine to the category of neuralgia. We report an adolescent girl with OM, who had been treated with steroid and showed dramatic improvement.


   Case Report Top


An 11-year-old girl presented with abrupt unilateral (right) ptosis and diplopia for 3 weeks [Figure 1]. At the beginning, it was associated with severe throbbing headache, pain in the right eye, nausea and recurrent vomiting. Within 7 days, except ptosis and diplopia, all other symptoms had spontaneously subsided. She had denied having trauma, fever, diurnal variation of ptosis, tinnitus, transient visual blurring or limb weakness. Past history revealed that she had experienced similar attacks 5-6 times in the past 4 years. In each episode, ptosis was unilateral and involved mostly right eyelid, but left eyelid was involved in one occasion. All episodes had been spontaneously resolved within 10-14 days. No family history of similar disease or migraine was obtained.
Figure 1: Image of face showing right sided ptosis

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Ophthalmologic examination revealed incomplete ptosis of the right eyelid and paresis of the right, upward and downward gaze. Pupil size was normal in the left eye and dilated in the right eye. Pupillary constriction was normal in the left eye and sluggish in the right eye to both direct and consensual light stimulation. There was absence of proptosis or congestion of both eyes. Acuity of vision without correction and intraocular pressure in both eyes were within normal limit. Fundus examination showed no pallor or edema of disc. Anterior and posterior segment examination as well as macula, vessels and periphery were normal. Neurological examination did not detect any other cranial nerve abnormality or limb weakness. Other systemic examinations yielded no abnormality.

Investigations including complete blood counts, erythrocyte sedimentation rate (ESR) and C-reactive protein, fasting blood sugar (FBS), thyroid function tests, antinuclear antibody (ANA) were within normal limits. MRI brain (plain and contrast) was also normal.

OM was taken as diagnosis and oral prednisolone (2 mg/kg/day) was started, which resulted in resolution of painful ophthalmoplegia within 7 days. Steroid was continued for weeks and then tapered off and antimigraine prophylaxis (flunarizine) was started. On follow-up, she is now attack free for the last 18 months.


   Discussion Top


Ophthalmoplegic migraine was named by Charcot in 1890; since then, it was being considered as a variant of migraine. [1] Clinical criteria for oculomotor OM are: 1) childhood onset, 2) headache preceding and ipsilateral to the third nerve paresis, 3) a dilated pupil, 4) ophthalmoplegia that may be permanent and rarely accompanied by aberrant oculomotor regeneration, 5) a minimum of two episodes and 6) no evidence for a structural lesion. [2] Recently, different pathogenic mechanisms, which include compressive, ischemic and inflammatory, have been suggested. [3] In some cases, MRI shows gadolinium uptake in the cisternal part of the affected cranial nerve. This suggests that the condition may be recurrent demyelinating cranial neuropathies. The recent revision of the IHCD-II has reclassified OM from a subtype of migraine to the category of neuralgia. [4] OM constitutes only 0.16% of childhood migraine. [5] Unlike our patient, it has a male predominance or occurs equally in both the sexes. Family history of typical OM is rarely positive. However, other varieties of migraine like "Common" or "Classic" are invariably found in family. Onset of disease in our patient was about 7 years of age, but majority of the patients experience initial attack in the first decade, usually before 5 years of age. Thus, the first attack is incorrectly attributed to aneurysm, trauma, infection or recent immunization; only when the condition resolves and recurs again, correct diagnosis is made. Rarely, patients experience their first attack in adulthood, but such patients mostly have a history of typical migraine headaches with or without aura since childhood or a family history of migraine or both. Approximately, 86% of patients of OM have transient, reversible MRI contrast enhancement of the affected cranial nerve. [3] Enhancement of the cisternal segment of the oculomotor nerve may be seen. Contrast-enhanced studies also showed focal thickening at the exit of the nerve in the interpeduncular cistern without enhancement of the cavernous sinus or adjacent dura. Enhancement is almost completely resolved about 7-9 weeks later. Although enhancement is associated with OM, it is not a sine qua non for the diagnosis of OM, as in our patient normal neuroimaging may be seen in OM. [6]

The differential diagnoses of OM include intracranial aneurysms or tumors, oculomotor nerve schwannoma, sphenoidal sinus mucoceles, raised intracranial tension (ICT) with brain herniation, Tolosa Hunt Syndrome (THS), myasthenia gravis (MG), and diabetic neuropathy. Although reported in a young child, intracranial aneurysm is extremely rare below 14 years of age. In our patient, the normal MRI brain excludes that diagnosis. In the case of oculomotor nerve schwannoma, slowly progressive weakness of the third nerve over the years is expected. That is also a less likely diagnosis because the patient's diplopia was recurrent and she was absolutely normal in between episodes. Mucocele of the sphenoidal sinus or tumors or inflammatory lesions that invade the cavernous sinus can cause painful ophthalmoplegia. However, the headache in such disorders is of rather gradual onset and is usually accompanied by systemic symptoms or signs of other cranial nerve palsies. In the index case, such types of lesions were excluded by proper neuroimaging. Raised ICT can cause herniation of hippocampal gyrus, producing an oculomotor paresis which may be transient, recurrent and associated with severe headache. In our patient, normal fundoscopic examination and absence of findings of brain herniation in MRI ruled out that diagnosis. Granulomatous diseases such as sarcoidosis or THS can cause oculomotor nerve palsy. THS is usually associated with meningeal enhancement on MRI. Evidence of inflammation in the superior orbital apex and cavernous sinus region supports a diagnosis of THS. However, proximal enlargement with gadolinium enhancement of the oculomotor nerve within the prepontine cistern has been reported both in OM and THS. [7] The girl had normal MRI brain; so, it was difficult to differentiate OM from THS on the basis of neuroimaging in our patient. However, THS is a disease of adults, associated with retro-orbital pain and is slow to resolve, especially without prednisone. In our patient, the previous histories of a recurrent third nerve palsy which resolved spontaneously and whose onset was associated with headache also made OM a more likely diagnosis. Ocular MG was a less likely diagnosis because there was absence of diurnal variations of ptosis and presence of pupil abnormality. If MG is highly suspected, then tensilon test may be done. Ophthalmoparesis due to uncontrolled diabetes mellitus (DM) rarely occurs in children. Besides DM, patients with hypertension, giant cell arteritis or other systemic vasculopathies may have ophthalmoparesis. However, that persisted longer than the ophthalmoplegia associated with OM. Normal FBS, ESR and CRP ruled out those possibilities. Although differential diagnosis is rather large, most other possible causes of ophthalmoplegia and headache have distinctive clinical presentations. As in our case, other causes should be excluded by proper neuroimaging.

Optimal prophylactic and acute treatment is still unclear, but migraine prophylactic medications such as beta blockers and calcium channel blockers have been proposed. Steroids have been used with mixed results. [8] As in our case, systemic steroids have shown promising results in other reports. [5] Prognosis is good because symptoms almost always resolve, but after several episodes, some deficits may persist.

 
   References Top

1.Charcot JM. Sur un cas de migraine ophtalmoplégique (paralysie oculo-motrice periodique). Prog Med (Paris) 1890;31:83-86;32:99- 102.   Back to cited text no. 1
    
2.Hansen SL, Borelli-Møller L, Strange P, Nielsen BM, Olesen J. Ophthalmoplegic migraine: Diagnostic criteria, incidence of hospitalization and possible etiology. Acta Neurol Scand 1990;81:54-60.  Back to cited text no. 2
    
3.Arasho BD. Ophthalmoplegic migraine in a 15-year-old Ethiopian: Case report and literature review. J Headache Pain 2009;10:45-9.   Back to cited text no. 3
    
4.Classification Committee of the International Headache Society. International classification of headache disorders II. Cephalalgia 2004;24(suppl 1):1-160.  Back to cited text no. 4
    
5.Afghani T. Ophthalmoplegic migraine. A case report and review of literature. Al-Shifa J Ophthalmol 2005;1:10-6.  Back to cited text no. 5
    
6.Ravishankar K. Ophthalmoplegic migraine: Still a diagnostic dilemma? Curr Pain Headache Rep 2008;12:285-91.  Back to cited text no. 6
    
7.Ramelli GP, Vella S, Lovblad K, Remonda L, Vassella F. Swelling of the third nerve in a child with transient oculomotor paresis: A possible cause of ophthalmoplegic migraine. Neuropediatrics 2000;31:145-7.  Back to cited text no. 7
    
8.Levin M, Ward TN. Ophthalmoplegic migraine. Curr Pain Headache Rep 2004;8:306-9.  Back to cited text no. 8
    


    Figures

  [Figure 1]


This article has been cited by
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[Pubmed]



 

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