home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 21      Small font sizeDefault font sizeIncrease font size Print this page Email this page


 
CASE REPORT
Year : 2010  |  Volume : 5  |  Issue : 1  |  Page : 36-38
 

Possible causes of seizure after spine surgery


1 Department of Neurosurgery, Imam Khomeini Hospital, Tehran, Iran
2 Children`s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
3 Hackensack University of Medical Center, Hackensack, NJ, USA

Date of Web Publication22-Jul-2010

Correspondence Address:
Farideh Nejat
Children`s Hospital Medical Center, Tehran University of Medical Sciences, Tehran
Iran
Login to access the Email id


DOI: 10.4103/1817-1745.66661

PMID: 21042506

Get Permissions

 

   Abstract 

Seizure after laminectomy for spinal procedure is very rare and has not been reported after lipomyelomeningocele surgery beforehand. Here, two cases of seizure following laminectomy for lipomyelomeningocele are reported. The exact etiology of the event is unknown but anesthetic material, pneumocephalus, intracranial hypotension subsequent to cerebrospinal fluid leakage after spinal procedures, spinal-induced seizure and the potential toxic effect of fat molecules could be considered.


Keywords: Lipomyelomeningocele, seizure, spinal-induced


How to cite this article:
Habibi Z, Nejat F, El Khashab M. Possible causes of seizure after spine surgery. J Pediatr Neurosci 2010;5:36-8

How to cite this URL:
Habibi Z, Nejat F, El Khashab M. Possible causes of seizure after spine surgery. J Pediatr Neurosci [serial online] 2010 [cited 2014 Nov 25];5:36-8. Available from: http://www.pediatricneurosciences.com/text.asp?2010/5/1/36/66661



   Introduction Top


Generalized seizure after laminectomy is very rare and, to our knowledge, has not been reported after lipomyelomeningocele surgery so far. Here, two cases of seizure following laminectomy for lumbar and lumbosacral lipomyelomeningocele are reported, and different aspects regarding the potential etiology of the event have been discussed.


   Case Report Top


Among all 107 cases of lipomyelomeningocele who underwent surgery in our center between 2000 and 2008, two patients developed generalized seizure postoperatively. One of them was a 7-month-old boy with lumbosacral transitional-type lipomyelomeningocele and the other was a 9-month-old boy with dorsal-type lipomyelomeningocele in the lumbar area. On admission, both patients had normal motor function but decreased anal sphincter tone and neurogenic bladder confirmed by urodynamic study. None of the children had a previous history of seizure. The patients had neither siblings with the same problem nor history of seizure in their families.

Preoperative laboratory tests were in the normal range. Standard surgical and anesthetic approach was performed in both patients. The patients were premedicated with fentanyl (1 μg/kg). Anesthesia was induced with inhalation of halothane and intravenous thiopental (5 mg/kg) and maintained with halothane at 1.5 minimum alveolar anesthetic concentration and N2O 50%. The patients then turned prone and standard surgery for lipomyelomeningocele was performed, including lipoma resection, releasing nerve roots, cord untethering, placode pial suturing and repairing dural and facial defects.

During surgery, no exogenous material entered the field and there was no antibiotic in the water for irrigation. Both patients were extubated in the operation room and transferred to the ward after uneventful recovery. The first patient developed generalized tonic clonic (GTC) seizure 2 hours after surgery, which was controlled with diazepam. The other had one episode of GTC seizure 12 hours after surgery, which was repeated on the next morning. Both attacks were controlled with phenytoin. Laboratory tests and serum electrolytes were normal in both patients. A brain computed tomography (CT) scan was performed in both, which was normal in the first case but revealed a small pneumocephalus of <1 cm thickness in the right frontal area in the second patient. There was no midline shift, edema or hematoma [Figure 1]. Electroencephalography was performed in both patients, which was normal.

Both patients were discharged from the hospital 7 days later and no episodes of seizure occurred afterwards.


   Discussions Top


The occurrence of seizure after laminectomy for the spinal procedure is very rare. Two cases of such complications have been reported after cervical and thoracic laminectomy, [1],[2] although seizure after laminectomy for lipomyelomeningocele has not been reported beforehand.

In myelomeningocele, which is a distinct entity, the range of seizure incidence varies from 14.7% to 29%. [3] Seizure in these patients is mainly related to the hydrocephalus, in particular, to the ventriculoperitoneal shunt and its complications. [3],[4] Considering the fact that these patients had lipomyelomeningocele, which never associated with hydrocephalus, the seizure cannot be attributed to this issue.

Different aspects related to the anesthetic course may cause postoperative seizure. However, anesthesia was managed without any hypotensive or hypoxic problems in these patients, with none of the agents being known to be epileptogenic.

Some cerebral and spinal mechanisms can be considered for a justification of the seizure after lipomyelomeningocele surgery. Pneumocephalus has been reported as a reason for generalized convulsion after cervical laminectomy, [2] as can be considered in one of these cases. Postoperative seizure after laminectomy may occur as a result of unrecognized dural tear, resulting in acute cerebrospinal fluid (CSF) loss and the drastic decrease in the CSF pressure. [1] Brain CT in such intracranial hypotension may show dural enhancement or meningeal reaction as decreased distance between the brain and the dura. [1] Different kinds of intracranial hemorrhage, particularly subdural, subsequent to CSF leakage after spinal procedures have been associated with seizure. [1],[5]

Some spinal basis can be supposed for this postoperative seizure. The issue of spinal-induced seizure is well documented in the literature and commonly used for experimental purposes. [6],[7] The investigations on vagus nerve stimulation on induced spinal cord seizure confirm the seizure with a merely spinal origin. [8] Neurons of the spinal cord, just as in the cerebral cortex, are known to become hyperactive and cause spinal cord ''seizures.'' [9] Transection of the spinal cord of the cat at a thoracic or lumbar level results in an altered excitability that repeated natural stimulation of the dermatome just caudal to the transection site will induce seizure discharges. [7] Spinal seizure has been reported in humans with transverse myelopathy as well. [10] Although our patients had no paresis before surgery and no cord injury happened during the procedure, it is possible that minor surgical manipulation had stimulated the neural pathways to act as a trigger zone for spinal seizure.

Spinal cord seizure can be induced with stimulation via numerous drugs and chemicals. Strychnine or tranexamic acid was shown to have such influences. [9] Topical or systemic administration of a toxic amount of penicillin can induce convulsive activity. [6] A case of postlaminectomy convulsion due to a large amount of iodophendylate used for preoperative myelogram has been reported as well. [11]

Regarding the fact that chemical spinal stimulation can trigger seizure and that no exogenous substance entered to our field during surgery, it can be considered that the fat molecules inside the lipoma may act as the source of stimulation. It is possible that these molecules were released from the fat tissue in their original form or even in the form of free radicals as a result of resection or thermal coagulation, and had a contact with exposed placode and cerebral neural structures and induced a trigger zone in the cord or brain.


   Conclusion Top


Although it cannot be determined by certainty, postsurgical seizure after lipomyelomeningocele operation in these cases can be attributed to either pneumocephalus or direct spinal stimulation through surgical manipulation or the potential toxic effect of fat molecules.

 
   References Top

1.Lin SM, Tsou MY, Chan KH, Yin YC, Hsin ST, Liao WW, et al. Myoclonic seizure in the postanesthesia care unit after thoracic laminectomy. Anesth Analg 2002;95:777-9.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Schwarz G, Tritthart H. Pneumocephalus--a possible cause of postoperative convulsions following cervical laminectomy. Anasth Intensivther Notfallmed 1987;22:239-41.  Back to cited text no. 2  [PUBMED]    
3.Battaglia D, Acquafondata C, Lettori D, Tartaglione T, Donvito V, Staccioli S, et al. Observation of continuous spike-waves during slow sleep in children with myelomeningocele. Childs Nerv Syst 2004;20:462-7.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]  
4.Talwar D, Baldwin MA, Horbatt CI. Epilepsy in children with meningomyelocele. Pediatr Neurol 1995;13:29-32.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]  
5.Siedschlag WD, Nisch G, Molsen HP. Cerebellar complications following operations in the spinal region. Zentralbl Neurochir 1985;46:251-5.  Back to cited text no. 5  [PUBMED]    
6.Lothman EW, Somjen GG. Motor and electrical signs of epileptiform activity induced by penicillin in the spinal cords of decapitate cats. Electroencephalogr Clin Neurophysiol 1976;41:237-52.  Back to cited text no. 6  [PUBMED]    
7.Yu Yu J, Chambers WW, Liu CN, Herdman SJ, Chen WP. Induction of spinal seizures by natural stimulation in cats. Brain Res 1984;299:323-30.  Back to cited text no. 7      
8.Tubbs RS, Killingsworth CR, Rollins DL, Smith WM, Ideker RE, Wellons JC 3 rd , et al. Vagus nerve stimulation for induced spinal cord seizures: insights into seizure cessation. J Neurosurg 2005;102:213-7.  Back to cited text no. 8      
9.Tubbs RS, Salter EG, Killingsworth C, Rollins DL, Smith WM, Ideker RE, et al. Right-Sided Vagus Nerve Stimulation Inhibits Induced Spinal Cord Seizures. Clin Anat 2007;20:23-6.  Back to cited text no. 9  [PUBMED]  [FULLTEXT]  
10.Cherrick AA, Ellenberg M. Spinal cord seizures in transverse myelopathy: Report of two cases. Arch Phys Med Rehabil 1986;67:129-32.  Back to cited text no. 10  [PUBMED]  [FULLTEXT]  
11.Jones DF. Postoperative convulsions due to iophendylate (Myodil). Report of a case and review of the causes of postoperative convulsions. Anaesthesia 1980;35:50-6.  Back to cited text no. 11  [PUBMED]    


    Figures

  [Figure 1]



 

Top
Print this article  Email this article
Previous article Next article

    

 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Article in PDF (428 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  


    Abstract
    Introduction
    Case Report
    Discussions
    Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed2265    
    Printed114    
    Emailed0    
    PDF Downloaded104    
    Comments [Add]    

Recommend this journal