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 INVITED REVIEW
Year : 2008  |  Volume : 3  |  Issue : 1  |  Page : 111-116

Neuromodulation for epilepsy


1 Department of Stereotactic and Functional Neurosurgery, Jaslok Hospital and Research Centre, Mumbai, India
2 In charge-Stereotactic and Functional Neurosurgery Program, Jaslok Hospital and Research Centre, Mumbai, India

Correspondence Address:
Paresh K Doshi
In charge - Stereotactic and Functional Neurosurgery Program, Jaslok Hospital and Research Centre, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.40599

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Epilepsy is a common disease. WHO data suggests that 1 in 20 people may have an epileptic seizure in their lifetime and at least 1 in 200 go on to develop epilepsy. Anticonvulsant drug therapy using one or more drugs works as an effective tool to suppress seizures in only 70% of the patients, the remaining 30% are either not responsive or suffer major side effects. Surgical resection then forms the next line of management in selected patients. However in some cases surgical resection may not be possible, hence arises the need for alternative therapies. Neuromodulation of the Central Nervous system is a novel technique under evaluation for Medically Intractable epilepsy. CNS stimulation for epilepsy has been a matter of extensive research. We review the Neurophysiological basis of Neuromodulation in Epilepsy and various modalities viz Vagal nerve stimulation (VNS), Transcranial magnetic stimulation (TMS) and Direct cortical stimulation (DCS). Deep brain stimulation (Hippocampal, Anterior thalamic and STN) and RNS are newer modalities and are also reviewed.






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