home : about us : ahead of print : current issue : archives search instructions : subscriptionLogin 
Users online: 239      Small font sizeDefault font sizeIncrease font size Print this page Email this page
 ORIGINAL ARTICLE
Year : 2006  |  Volume : 1  |  Issue : 2  |  Page : 49-55

Medulloblastoma in children: Birmingham experience


Birmingham Children's Hospital, Birmingham, United Kingdom

Correspondence Address:
Anil Sivasankaran
67, Persiaran Blm 2, Bandar Laguna Merbok, 08000, Sungai Petan, Kedah, Malaysia

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.27453

Rights and Permissions

A retrospective review of 41 children diagnosed with medulloblastoma in Birmingham (United Kingdom) between 1992-2002 presented. The age of the patients ranged from 2 weeks to 14.1 years (mean 5.89 years) and the mean follow-up was 3.8 years. Children less than 3 years of age fared worse than those over 3 years. The 5-year survival with total and subtotal tumor excision was 61.3 and 40% respectively. Those children who received radiotherapy following surgery had an improved survival of 68% at 5 years as compared to 18% in those who did not receive irradiation. With regards to chemotherapy, the 5-year survival rates were 57% in those who received it and 52% in those who did not. The overall survival was 62% at 5 years for those patients who had postoperative combined radiotherapy and chemotherapy and only 48% for the rest, who received no adjuvant therapy. Age of the patient has a definite influence on overall survival. We found significant statistical difference in survival between patients with total tumor resection and those with subtotal resection. The 5-year survival rate was not directly affected by tumor location, hydrocephalus or ventriculo-peritoneal shunting. Postoperative irradiation and chemotherapy are clearly associated with improved survival.






[FULL TEXT] [PDF]*


        
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed9076    
    Printed256    
    Emailed4    
    PDF Downloaded313    
    Comments [Add]    
    Cited by others 1    

Recommend this journal