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 REVIEW ARTICLE
Year : 2006  |  Volume : 1  |  Issue : 1  |  Page : 5-10

Primer on pediatric intracranial ependymomas


Department of Neurosurgery, Himalayan Institute of Medical Sciences, Dehradun, UA, India

Correspondence Address:
K K Bansal
Department of Neurosurgery, Himalayan Institute of Medical Sciences, Dehradun, UA
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1817-1745.22940

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Aims and Objectives: To review the clinical features and current understanding of the biology and management of pediatric ependymoma, critically analysing the different treatment modalities. Materials and Methods: The MEDLINE database, bibliographies of selected articles, and current English-language texts on the subject were reviewed. A Pubmed search was made with keywords pediatric, intracranial, ependymoma, surgery, chemotherapy, and radiotherapy. Most recent articles and also significant older articles having all above said words were selected and their results were compared in detail. Results: Almost all articles stress the complete or near total resection of the tumor at first surgery followed by radiotherapy in patients older than 3 years of age and chemotherapy in younger children. Conformal radiation therapy (CRT) is a technique which has promising results. Conclusion: Local tumor control is single most important prognostic factor. This is best achieved through gross total tumor resection wherever possible. Radiotherapy should be offered to all patients (>3-years age) with focused dose (CRT) to tumor bed. Chemotherapy with the current agents does not appear to hold much promise. However, it may be useful in the context of providing the surgeon with an opportunity to do further surgery on a tumor that is less vascularized.






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